BDBM50298809 (+/-)-5-(3-(4',5-dimethoxybiphenyl-3-yl)but-1-ynyl)-6-methylpyrimidine-2,4-diamine::Biphenyl antifolate, 25::CHEMBL572485

SMILES COc1ccc(cc1)-c1cc(OC)cc(c1)C(C)C#Cc1c(C)nc(N)nc1N

InChI Key InChIKey=SWYJGRLYDXSLBS-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50298809   

TargetDihydrofolate reductase(Candida Glabrata)
University of Connecticut

LigandPNGBDBM50298809((+/-)-5-(3-(4',5-dimethoxybiphenyl-3-yl)but-1-ynyl...)
Affinity DataIC50:  6.40nMAssay Description:Enzyme activity assay were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over 5 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Candida albicans)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298809((+/-)-5-(3-(4',5-dimethoxybiphenyl-3-yl)but-1-ynyl...)
Affinity DataIC50:  30nMAssay Description:Inhibition of Candida albicans DHFR expressed in Escherichia coli BL21 (DE3) assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298809((+/-)-5-(3-(4',5-dimethoxybiphenyl-3-yl)but-1-ynyl...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human DHFR assessed as rate of NADPH consumption using dihydrofolate as susbtrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50298809((+/-)-5-(3-(4',5-dimethoxybiphenyl-3-yl)but-1-ynyl...)
Affinity DataIC50:  180nMAssay Description:Enzyme activity assay were performed by monitoring the rate of enzyme-dependent NADPH consumption at an absorbance of 340 nm over 5 min.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed