BDBM50303719 2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one::CHEMBL566200::rac-2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3-(pyridin-3-yl)phenyl)-1H-imidazol-5(4H)-one

SMILES COc1ccc(cc1C)C1(N=C(N)N(C)C1=O)c1cccc(c1)-c1cccnc1

InChI Key InChIKey=TWVGNKMRZLBNOD-UHFFFAOYSA-N

Data  8 IC50  1 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50303719   

TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303719(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Affinity DataEC50:  120nMAssay Description:Inhibition of BACE1 expressed in CHOK1 cells coexpressing human recombinant wild type APP assessed as blockade of amyloid beta production by ELISAMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303719(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303719(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1 by FRET assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303719(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human BACE1More data for this Ligand-Target Pair
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303719(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  790nMAssay Description:Inhibition of human BACE2 by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303719(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of human cathepsin D by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303719(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  9.34E+4nMAssay Description:Inhibition of human recombinant renin by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303719(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  1.25E+4nMAssay Description:Inhibition of human cathepsin D by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50303719(2-amino-4-(4-methoxy-3-methylphenyl)-1-methyl-4-(3...)
Affinity DataIC50:  780nMAssay Description:Inhibition of human BACE2 by FRET based peptide cleavage assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed