BDBM50307137 (3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one::(Z)-5-Amino-3-(3,5-dimethyl-1H-pyrrol-2-ylmethylene)-1,3-dihydro-indol-2-one::CHEMBL597181

SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(N)cc23)[nH]1

InChI Key InChIKey=XYONNOXYJMPBMA-GHXNOFRVSA-N

Data  4 IC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50307137   

TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307137((3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methy...)
Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(N)cc23)[nH]1
Show InChI InChI=1S/C15H15N3O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,16H2,1-2H3,(H,18,19)/b12-7-
Affinity DataIC50: 630nMAssay Description:Inhibition of FLT3 by ELISA-based kinase assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307137((3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methy...)
Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(N)cc23)[nH]1
Show InChI InChI=1S/C15H15N3O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,16H2,1-2H3,(H,18,19)/b12-7-
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant His-tagged RET expressed in Sf9 insect cellsMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307137((3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methy...)
Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(N)cc23)[nH]1
Show InChI InChI=1S/C15H15N3O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,16H2,1-2H3,(H,18,19)/b12-7-
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of ALK by ELISA-based kinase assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
University of Milano-Bicocca

Curated by ChEMBL
LigandPNGBDBM50307137((3Z)-5-amino-3-[(3,5-dimethyl-1H-pyrrol-2-yl)methy...)
Show SMILES Cc1cc(C)c(\C=C2/C(=O)Nc3ccc(N)cc23)[nH]1
Show InChI InChI=1S/C15H15N3O/c1-8-5-9(2)17-14(8)7-12-11-6-10(16)3-4-13(11)18-15(12)19/h3-7,17H,16H2,1-2H3,(H,18,19)/b12-7-
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of ABL by ELISA-based kinase assayMore data for this Ligand-Target Pair