BDBM50311894 CHEMBL1087638::N-(3-(1-(6-(2-hydroxyethylamino)pyrimidin-4-yl)-1H-benzo[d]imidazol-2-ylamino)-4-methylphenyl)-3-(trifluoromethyl)benzamide

SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1Nc1nc2ccccc2n1-c1cc(NCCO)ncn1

InChI Key InChIKey=HHVUDVWMACNSOB-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50311894   

TargetTyrosine-protein kinase Lck(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311894BDBM50311894(N-(3-(1-(6-(2-hydroxyethylamino)pyrimidin-4-yl)-1H...)
Affinity DataIC50: 27nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase HCK(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311894BDBM50311894(N-(3-(1-(6-(2-hydroxyethylamino)pyrimidin-4-yl)-1H...)
Affinity DataIC50: 192nMAssay Description:Inhibition of HCKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lck(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311894BDBM50311894(N-(3-(1-(6-(2-hydroxyethylamino)pyrimidin-4-yl)-1H...)
Affinity DataIC50: 229nMAssay Description:Inhibition of Tel-fused LCK expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetTyrosine-protein kinase Lyn(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311894BDBM50311894(N-(3-(1-(6-(2-hydroxyethylamino)pyrimidin-4-yl)-1H...)
Affinity DataIC50: 400nMAssay Description:Inhibition of Tel-fused LYN expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311894BDBM50311894(N-(3-(1-(6-(2-hydroxyethylamino)pyrimidin-4-yl)-1H...)
Affinity DataIC50: 590nMAssay Description:Inhibition of Tel-fused KDR expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311894BDBM50311894(N-(3-(1-(6-(2-hydroxyethylamino)pyrimidin-4-yl)-1H...)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of Tel-fused SRC expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311894BDBM50311894(N-(3-(1-(6-(2-hydroxyethylamino)pyrimidin-4-yl)-1H...)
Affinity DataIC50: 1.92E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Genomics Institute of The Novartis Research Foundation

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50311894BDBM50311894(N-(3-(1-(6-(2-hydroxyethylamino)pyrimidin-4-yl)-1H...)
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of Tel-fused InsR expressed in mouse BAF3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/17/2010
Entry Details Article
PubMed