BDBM50314051 CHEMBL1089082::N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-yl)phenyl)-3-(trifluoromethyl)benzamide

SMILES: FC(F)(F)c1cccc(c1)C(=O)Nc1cccc(c1)-c1ccnc2cc(nn12)-c1ccncc1

InChI Key: InChIKey=LCMNWMABPDVIPG-UHFFFAOYSA-N

Data: 25 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 25 hits for monomerid = 50314051   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Rho-associated protein kinase 1 (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase B-raf (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase kinase kinase 8 (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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3-phosphoinositide-dependent protein kinase 1 (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase mTOR (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Lck (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Insulin-like growth factor 1 receptor (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase PLK1 (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Mitogen-activated protein kinase kinase kinase kinase 2 (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase ABL1 (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Tyrosine-protein kinase Fyn (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Proto-oncogene tyrosine-protein kinase Src (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Serine/threonine-protein kinase Chk1 (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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MAP kinase-activated protein kinase 2 (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Mitogen-activated protein kinase 14 (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 1 (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Inhibitor of nuclear factor kappa-B kinase subunit beta (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Protein kinase C beta type (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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RAC-alpha serine/threonine-protein kinase (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 2 (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase B-raf (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	32	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Protein kinase C alpha type (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1 (Human)	BDBM50314051 (N-(3-(2-(pyridin-4-yl)pyrazolo[1,5-a]pyrimidin-7-y...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>5.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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