BDBM50315203 (R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-6-methyl-1H-inden-2-yl)-N,N-dimethylethanamine::CHEMBL1090176

SMILES COc1nccnc1[C@H](C)C1=C(CCN(C)C)Cc2cc(C)ccc12

InChI Key InChIKey=LHYWGVZKOTTYSZ-OAHLLOKOSA-N

Data  4 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50315203   

TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315203((R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-6-methyl...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity at histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H1 receptor(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315203((R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-6-methyl...)
Affinity DataKi:  2.70nMAssay Description:Inhibition of histamine H1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315203((R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-6-methyl...)
Affinity DataKi: >3.00E+3nMAssay Description:Displacement of dofetilide from human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315203((R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-6-methyl...)
Affinity DataKi: >1.00E+4nMAssay Description:Binding affinity at M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315203((R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-6-methyl...)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315203((R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-6-methyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315203((R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-6-methyl...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315203((R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-6-methyl...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Neurocrine Biosciences

Curated by ChEMBL
LigandPNGBDBM50315203((R)-2-(3-(1-(3-methoxypyrazin-2-yl)ethyl)-6-methyl...)
Affinity DataIC50:  1.10E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed