BDBM50319616 1-(4-(4-(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-ylamino)phenyl)piperazin-1-yl)ethanone::CHEMBL1084969

SMILES CC(=O)N1CCN(CC1)c1ccc(Nc2nccc(n2)-c2sc(N)nc2C)cc1

InChI Key InChIKey=ZBYYPNTVDDUJTC-UHFFFAOYSA-N

Data  7 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50319616   

TargetAurora kinase B(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319616(1-(4-(4-(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin...)
Affinity DataKi:  3.80nMAssay Description:Inhibition of human recombinant Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319616(1-(4-(4-(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin...)
Affinity DataKi:  7.60nMAssay Description:Inhibition of human recombinant Aurora A after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 9(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319616(1-(4-(4-(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin...)
Affinity DataKi:  264nMAssay Description:Inhibition of CDK9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319616(1-(4-(4-(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin...)
Affinity DataKi:  522nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319616(1-(4-(4-(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin...)
Affinity DataKi:  1.25E+3nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319616(1-(4-(4-(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin...)
Affinity DataKi:  2.15E+3nMAssay Description:Inhibition of CDK7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Cyclacel

Curated by ChEMBL
LigandPNGBDBM50319616(1-(4-(4-(4-(2-Amino-4-methylthiazol-5-yl)pyrimidin...)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed