BDBM50320969 CHEMBL1164353::Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxylic acidisobutyl-methyl-amide

SMILES CC(C)CN(C)C(=O)c1ccc2cc([nH]c2c1)-c1n[nH]cc1-c1ccccc1

InChI Key InChIKey=XZHOYHKWBQJJRK-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50320969   

TargetTyrosine-protein kinase ITK/TSK(Human)
Nycomed Pharma

Curated by ChEMBL
LigandPNGBDBM50320969(Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxylic aci...)
Affinity DataIC50: 330nMAssay Description:Inhibition of GST-tagged full length recombinant ITK after 2 hrs by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Nycomed Pharma

Curated by ChEMBL
LigandPNGBDBM50320969(Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxylic aci...)
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of GST-tagged full length CDK2/Cyclin E after 40 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetGlycogen synthase kinase-3 beta(Human)
Nycomed Pharma

Curated by ChEMBL
LigandPNGBDBM50320969(Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxylic aci...)
Affinity DataIC50: 6.76E+3nMAssay Description:Inhibition of GST-tagged full length GSK3-beta assessed as inhibition of ATP consumption after 60 mins by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed
TargetInsulin receptor(Human)
Nycomed Pharma

Curated by ChEMBL
LigandPNGBDBM50320969(Phenyl-1H-pyrazol-3-yl)-1H-indole-6-carboxylic aci...)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of GST-tagged recombinant INSR catalytic domain expressed in baculovirus-infected Sf21 cells after 80 mins by IMAP assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/20/2010
Entry Details Article
PubMed