BDBM503335 2-((R)-6-Amino-2-aza- spiro[4.4]non-2-yl)-5-(2,3-dichloro- phenyl)-6-methyl-pyrimidine-4- carboxylic acid amide::US11033547, Compound 35::US11696916, Compound 35

SMILES Cc1nc(nc(C(N)=O)c1-c1cccc(Cl)c1Cl)N1CCC2(CCC[C@H]2N)C1

InChI Key InChIKey=AZIVYVCMTYVJJH-QMRFKDRMSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 503335   

TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens)
Merck Patent

US Patent
LigandPNGBDBM503335(2-((R)-6-Amino-2-aza- spiro[4.4]non-2-yl)-5-(2,3-d...)
Affinity DataIC50:  1.10E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Merck Patent

US Patent
LigandPNGBDBM503335(2-((R)-6-Amino-2-aza- spiro[4.4]non-2-yl)-5-(2,3-d...)
Affinity DataIC50:  1.10E+3nMAssay Description:The inhibition of SHP2 by compounds of the invention was monitored using the surrogate substrate DiFMUP after protein activation by a peptide bearing...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent