BDBM50337926 (R)-3-(2,3-dihydroxypropyl)-6-fluoro-5-(2-fluoro-4-iodophenylamino)-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione::3-[(2R)-2,3-dihydroxypropyl]-6-fluoro-5-[(2-fluoro-4-iodophenyl)amino]-8-methylpyrido[2,3-d]pyrimidine-4,7(3H,8H)-dione::CHEMBL1615025::US8470837, 18
SMILES Cn1c2ncn(C[C@@H](O)CO)c(=O)c2c(Nc2ccc(I)cc2F)c(F)c1=O
InChI Key InChIKey=RCLQNICOARASSR-SECBINFHSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50337926
TargetDual specificity mitogen-activated protein kinase kinase 1 [2-31,52-393,S218E,S222D](Human)
Takeda Pharmaceutical
US Patent
Takeda Pharmaceutical
US Patent
Affinity DataIC50: <5nMpH: 7.3 T: 25°CAssay Description:Reaction product is determined quantitatively by fluorescent polarization using progressive IMAP beads from Molecular Devices.More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda California
Curated by ChEMBL
Takeda California
Curated by ChEMBL
Affinity DataIC50: 3.20nMAssay Description:Inhibition of MEK1 by IMAP assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda California
Curated by ChEMBL
Takeda California
Curated by ChEMBL
Affinity DataIC50: 1.80nMAssay Description:Inhibition of MEK1 (unknown origin)More data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Human)
Takeda California
Curated by ChEMBL
Takeda California
Curated by ChEMBL
Affinity DataIC50: 6.90nMAssay Description:Inhibition of MEK1 in human COLO205 cellsMore data for this Ligand-Target Pair