BDBM50355142 CHEMBL1835919
SMILES Nc1ncnc2OCCN(c3ccc(cc3)[C@H]3CC[C@H](CC(O)=O)CC3)C(=O)c12
InChI Key InChIKey=GEVVQZHMFVFGLN-HDJSIYSDSA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50355142
Affinity DataIC50: 8nMAssay Description:Inhibition of DGAT-1-mediated triglyceride synthesis in human HT-29 cells using [3H]-glycerol as substrate incubated for 1 hr prior to substrate addi...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human full length DGAT-1 expressed in insect sf9 cells using [14C]decanoylCoA as substrate after 1.5 hrs by scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Inhibition of recombinant human DGAT-1 expressed in Hep3B cell lysate using didecanoyl glycerol and [14C]decanoyl-CoA as substrate after 60 mins by l...More data for this Ligand-Target Pair
TargetDiacylglycerol O-acyltransferase 1(Mus musculus (mouse))
Korea Research Institute Of Chemical Technology
Curated by ChEMBL
Korea Research Institute Of Chemical Technology
Curated by ChEMBL
Affinity DataIC50: 88nMAssay Description:Inhibition of DGAT-1 in mouse liver microsomes using didecanoyl glycerol and [14C]decanoyl-CoA as substrate after 60 mins by liquid scintillation cou...More data for this Ligand-Target Pair
Affinity DataIC50: 64nMAssay Description:Inhibition of rat DGAT-1More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of human DGAT-1-mediated triglyceride synthesis in the HT-29 cells by whole cell assayMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of full length human microsomal DGAT-1 expressed in baculovirus infected insect Sf9 cells using [14C]decanoylCoA as substrate after 1.5 hr...More data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of human DGAT-2More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of DGAT1-mediated triglyceride synthesis in human HT-29 cells using [3H]glycerol as substrate after 6 hrs by beta countingMore data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of human DGAT1More data for this Ligand-Target Pair