BDBM50379186 CEP-11981::CHEMBL2010872

SMILES CC(C)Cn1c2ccc(Nc3ncccn3)cc2c2c3CNC(=O)c3c3-c4cn(C)nc4CCc3c12

InChI Key InChIKey=AEULIVPVIDOLIN-UHFFFAOYSA-N

Data  2 KI  25 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 27 hits for monomerid = 50379186   

TargetAdenosine receptor A2a(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataKi:  500nMAssay Description:Inhibition of adenosine A2A receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M4(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataKi:  2.90E+3nMAssay Description:Inhibition of muscarinic M4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  2.00E+4nMAssay Description:Inhibition of human Erg expressed CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  5nMAssay Description:Inhibition of human TRK-B using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  3nMAssay Description:Inhibition of human TRK-A using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 2 group C member 2(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  14nMAssay Description:Inhibition of human TAK1 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  5nMAssay Description:Inhibition of human RET using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  246nMAssay Description:Inhibition of human PDGFRalpha using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 3(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  21nMAssay Description:Inhibition of human MST2 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  78nMAssay Description:Inhibition of human FMS using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  71nMAssay Description:Inhibition of human FLT3 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  3nMAssay Description:Inhibition of human VEGFR1 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  89nMAssay Description:Inhibition of human FGFR3 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  13nMAssay Description:Inhibition of human FGFR1 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  37nMAssay Description:Inhibition of human cSrc using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCasein kinase I isoform alpha(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  48nMAssay Description:Inhibition of CK1 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  140nMAssay Description:Inhibition of human CHK2 using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  93nMAssay Description:Inhibition of human BTK using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  42nMAssay Description:Inhibition of human Aurora-A using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  132nMAssay Description:Inhibition of human ALK using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  9.00E+3nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  50nMAssay Description:Inhibition of human Tie2 expressed in porcine PAE145 cells cotransfected with chimeric rat TRK-A/KDR receptor after 1 hr by immunofluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant VEGF-R2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluore...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Mus musculus)
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  8nMAssay Description:Inhibition of mouse BLK using ATP as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiopoietin-1 receptor(Homo sapiens (Human))
Cephalon Inc

Curated by ChEMBL
LigandPNGBDBM50379186(CEP-11981 | CHEMBL2010872)
Affinity DataIC50:  22nMAssay Description:Inhibition of human recombinant Tie2 expressed in baculovirus expression system using GST-PLCgamma as substrate after 1 hr by time-resolved fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed