BDBM50382048 CHEMBL2022739

SMILES Fc1ccccc1C(=O)Nc1ccc(-c2nnc(NCCCCN3CCOCC3)o2)c(F)c1

InChI Key InChIKey=JZLFWWQOPQHUPT-UHFFFAOYSA-N

Data  10 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 50382048   

TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50382048(CHEMBL2022739)
Affinity DataEC50:  126nMAssay Description:Agonist activity at human alpha7 nAChR expressed in GH4C1 cells by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50382048(CHEMBL2022739)
Affinity DataIC50:  3.98E+4nMAssay Description:Displacement of [3H]Dofetilide from human ERG expressed in CHO-K1 cells by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50382048(CHEMBL2022739)
Affinity DataIC50:  1.86E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50382048(CHEMBL2022739)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50382048(CHEMBL2022739)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50382048(CHEMBL2022739)
Affinity DataIC50:  7.94E+3nMAssay Description:Antagonist activity at alpha4beta2 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50382048(CHEMBL2022739)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50382048(CHEMBL2022739)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CYP3A4 using diethoxyfluorescein as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50382048(CHEMBL2022739)
Affinity DataIC50:  6.40E+4nMAssay Description:Inhibition of CYP3A4 using 7-benzyloxyquinoline as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholine receptor subunit alpha(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50382048(CHEMBL2022739)
Affinity DataIC50:  6.31E+3nMAssay Description:Antagonist activity at alpha1 nAChRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50382048(CHEMBL2022739)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed