BDBM50390028 CHEMBL2069398

SMILES Cc1cccc(c1)-c1noc(n1)C1CN(C(=O)C1)c1ccc(F)cc1

InChI Key InChIKey=IGUGPXBOXUANHO-UHFFFAOYSA-N

Data  1 KI  7 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50390028   

TargetMetabotropic glutamate receptor 5(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50390028(CHEMBL2069398)
Affinity DataEC50:  12.5nMAssay Description:Positive allosteric modulation of human mGluR5 expressed in HEK293A cells assessed as stimulation of glutamate-induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50390028(CHEMBL2069398)
Affinity DataEC50:  12.5nMAssay Description:Positive allosteric modulation of human mGluR5 expressed in HEK293A cells assessed as stimulation of glutamate-induced calcium flux by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetMetabotropic glutamate receptor 5(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50390028(CHEMBL2069398)
Affinity DataKi:  230nMAssay Description:Displacement of [3H]NAM from mGluR5More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50390028(CHEMBL2069398)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50390028(CHEMBL2069398)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human ERG by patch clamp assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50390028(CHEMBL2069398)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50390028(CHEMBL2069398)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCytochrome P450 1A2(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50390028(CHEMBL2069398)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50390028(CHEMBL2069398)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Lundbeck Research Usa

Curated by ChEMBL
LigandPNGBDBM50390028(CHEMBL2069398)
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed