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BDBM504211 (8S)-3′-[2,6-Difluoro-4-(2-phenylethynyl)phenyl]-1′-methyl-spiro[6,7-dihydro-5H-isoquinoline-8,6′-hexahydropyrimidine]-2′,4′-dione::US11034699, Example 1

SMILES: CN1C(=O)N(C(=O)C[C@]11CCCc2ccncc12)c1c(F)cc(cc1F)C#Cc1ccccc1

InChI Key: InChIKey=BASKATXGQBKLBA-MHZLTWQESA-N

Data: 1 EC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 504211   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor 4


(Homo sapiens (Human))
BDBM504211
PNG
((8S)-3′-[2,6-Difluoro-4-(2-phenylethynyl)phe...)
Show SMILES CN1C(=O)N(C(=O)C[C@]11CCCc2ccncc12)c1c(F)cc(cc1F)C#Cc1ccccc1
Show InChI InChI=1S/C27H21F2N3O2/c1-31-26(34)32(24(33)16-27(31)12-5-8-20-11-13-30-17-21(20)27)25-22(28)14-19(15-23(25)29)10-9-18-6-3-2-4-7-18/h2-4,6-7,11,13-15,17H,5,8,12,16H2,1H3/t27-/m0/s1
PDB

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US Patent
n/an/an/an/a 58n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
A monoclonal HEK-293 cell line stably transfected with a cDNA encoding for the human mGlu4 receptor was generated; for the work with mGlu4 Positive A...


US Patent US11034699 (2021)

More data for this
Ligand-Target Pair