BDBM50433845 CHEMBL2382400

SMILES NS(=O)(=O)c1ccc(NC(=O)CSc2nc(-c3ccccc3)c(C#N)c(=O)[nH]2)cc1

InChI Key InChIKey=AVLZXGPNSNUAOM-UHFFFAOYSA-N

Data  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50433845   

TargetCarbonic anhydrase 2(Human)TBA
LigandPNGBDBM50433845(CHEMBL2382400)
Affinity DataKi:  6.5nMAssay Description:Inhibition of human CA2 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 12(Human)TBA
LigandPNGBDBM50433845(CHEMBL2382400)
Affinity DataKi:  29nMAssay Description:Inhibition of human CA12 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 9(Human)TBA
LigandPNGBDBM50433845(CHEMBL2382400)
Affinity DataKi:  38nMAssay Description:Inhibition of human CA9 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetCarbonic anhydrase 1(Human)TBA
LigandPNGBDBM50433845(CHEMBL2382400)
Affinity DataKi:  594nMAssay Description:Inhibition of human CA1 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped-flow CO2 hydration assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
TBA
Entry Details
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50433845(CHEMBL2382400)
Affinity DataIC50: 1.21E+4nMAssay Description:Inhibition of human recombinant carboxy-terminal his-tagged LDHA (1 to 331) expressed in Escherichia coli using pyruvate as substrate after 10 mins b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetL-lactate dehydrogenase A chain(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50433845(CHEMBL2382400)
Affinity DataKd:  1.54E+4nMAssay Description:Binding affinity to human recombinant carboxy-terminal avi-tagged LDHA (1 to 331) expressed in Escherichia coli by surface plasmon resonance analysis...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed
TargetL-lactate dehydrogenase B chain(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50433845(CHEMBL2382400)
Affinity DataIC50: 4.28E+4nMAssay Description:Inhibition of human recombinant carboxy-terminal his-tagged LDHB (1 to 333) expressed in insect cells using pyruvate as substrate after 10 mins by UV...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/13/2014
Entry Details Article
PubMed