BDBM50436514 CHEMBL2397377

SMILES C[C@@H]1CN(CCN1c1ccncn1)C(=O)C12CC3CC(CC(C3)C1)C2

InChI Key InChIKey=CFLBXSNLGVYEBB-ZIUDEIKKSA-N

Data  2 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50436514   

TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50436514(CHEMBL2397377)
Show SMILES C[C@@H]1CN(CCN1c1ccncn1)C(=O)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C20H28N4O/c1-14-12-23(4-5-24(14)18-2-3-21-13-22-18)19(25)20-9-15-6-16(10-20)8-17(7-15)11-20/h2-3,13-17H,4-12H2,1H3/t14-,15?,16?,17?,20?/m1/s1
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human mGluR1 expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 1(Homo sapiens (Human))
Vanderbilt University Medical Center

Curated by ChEMBL
LigandPNGBDBM50436514(CHEMBL2397377)
Show SMILES C[C@@H]1CN(CCN1c1ccncn1)C(=O)C12CC3CC(CC(C3)C1)C2
Show InChI InChI=1S/C20H28N4O/c1-14-12-23(4-5-24(14)18-2-3-21-13-22-18)19(25)20-9-15-6-16(10-20)8-17(7-15)11-20/h2-3,13-17H,4-12H2,1H3/t14-,15?,16?,17?,20?/m1/s1
Affinity DataIC50: 1.00E+4nMAssay Description:Negative allosteric modulation of human mGluR1 expressed in HEK293A cells assessed as inhibition of glutamate-induced calcium mobilizationMore data for this Ligand-Target Pair