BDBM50438865 2,4-Dioxo-10-phenyl-pyrimido[4,5-b]quinoline-8-carbonitrile (3)::CHEMBL2420506

SMILES: O=c1nc2n(-c3ccccc3)c3cc(ccc3cc2c(=O)[nH]1)C#N

InChI Key: InChIKey=KJCUSTLTHCEPIZ-UHFFFAOYSA-N

Data: 9 IC50  1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50438865   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosyl-DNA phosphodiesterase 2 (Human)	BDBM50438865 (CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	300	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Human)	BDBM50438865 (CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	180	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Mouse)	BDBM50438865 (CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.11E+5	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321C] (Mouse)	BDBM50438865 (CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.70E+3	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 [E242G,S244A,Q278R,I281T,K282R,R316G,P318T,Y321CH323L] (Mouse)	BDBM50438865 (CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	260	n/a	n/a	n/a	n/a	7.5	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Human)	BDBM50438865 (CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	640	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Human)	BDBM50438865 (CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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DNA-(apurinic or apyrimidinic site) endonuclease (Human)	BDBM50438865 (CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>2.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Human)	BDBM50438865 (CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	3.71E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Tyrosyl-DNA phosphodiesterase 2 (Human)	BDBM50438865 (CHEMBL2420506 | 2,4-Dioxo-10-phenyl-pyrimido[4,5-b...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	500	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair