BDBM50444605 CHEMBL3099899
SMILES COc1ccc(CNC(=O)c2cc(cnc2-c2cccnc2)-c2cc(Cl)cc(Cl)c2)cc1OC
InChI Key InChIKey=VDWKDBPHAPPUBO-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50444605
Affinity DataKi: 0.0700nMAssay Description:Displacement of [3H]SB-674042 from human orexin-2 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataKi: 95nMAssay Description:Displacement of [3H]SB-674042 from human orexin-1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Research Laboratories
Curated by ChEMBL
Merck Research Laboratories
Curated by ChEMBL
Affinity DataIC50: 292nMAssay Description:Antagonist activity at human orexin-1 receptor assessed as inhibition of orexin-A-induced intracellular calcium mobilization after 30 mins by cell-ba...More data for this Ligand-Target Pair
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human orexin-2 receptor assessed as inhibition of orexin-A-induced intracellular calcium mobilization after 30 mins by cell-ba...More data for this Ligand-Target Pair