BDBM50444605 CHEMBL3099899

SMILES COc1ccc(CNC(=O)c2cc(cnc2-c2cccnc2)-c2cc(Cl)cc(Cl)c2)cc1OC

InChI Key InChIKey=VDWKDBPHAPPUBO-UHFFFAOYSA-N

Data  2 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50444605   

TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50444605(CHEMBL3099899)
Affinity DataKi:  0.0700nMAssay Description:Displacement of [3H]SB-674042 from human orexin-2 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50444605(CHEMBL3099899)
Affinity DataKi:  95nMAssay Description:Displacement of [3H]SB-674042 from human orexin-1 receptor after 60 mins by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin/Hypocretin receptor type 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50444605(CHEMBL3099899)
Affinity DataIC50:  292nMAssay Description:Antagonist activity at human orexin-1 receptor assessed as inhibition of orexin-A-induced intracellular calcium mobilization after 30 mins by cell-ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOrexin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50444605(CHEMBL3099899)
Affinity DataIC50:  12nMAssay Description:Antagonist activity at human orexin-2 receptor assessed as inhibition of orexin-A-induced intracellular calcium mobilization after 30 mins by cell-ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed