BDBM50448771 CHEMBL3128042

SMILES COCCNc1nc2ccc(cc2n1-c1ccnc(N)n1)C#CC1(O)CCCCC1

InChI Key InChIKey=RZXMIHOUHYSGJO-UHFFFAOYSA-N

Data  2 KI  8 IC50

PDB links: 2 PDB IDs match this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50448771   

TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataKi:  3.30nMAssay Description:Binding affinity to N-terminal GST-tagged recombinant human PAK4 kinase domain expressed in Escherichia coli using KKRNRRLSVA as substrate preincubat...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataKi:  2.90E+3nMAssay Description:Binding affinity to N-terminal GST-His-tagged recombinant human PAK1 kinase domain expressed in Escherichia coli BL21 using KKRNRRLSVA as sustrate pr...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 3(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PAK3 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 6(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50:  36nMAssay Description:Inhibition of PAK6 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50:  7.5nMAssay Description:Inhibition of PAK4 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 2(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50:  970nMAssay Description:Inhibition of PAK2 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50:  5.42E+3nMAssay Description:Inhibition of PAK1 (unknown origin)More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 4(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human recombinant PAK4 kinase domain assessed as phosphorylation of FRET peptide substrate at Ser/Thr20 by Zylite assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human recombinant PAK1 kinase domain assessed as phosphorylation of FRET peptide substrate at Ser/Thr20 by Zylite assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PAK 5(Homo sapiens (Human))
Genentech

Curated by ChEMBL
LigandPNGBDBM50448771(CHEMBL3128042)
Affinity DataIC50:  126nMAssay Description:Inhibition of PAK5 (unknown origin)More data for this Ligand-Target Pair