BDBM504502 From first-eluting enantiomer of intermediate (see footnote 7, Table 1); N-[(3S)-4,4-difluoropiperidin-3-yl]-2- {5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3- yl}pyrimidine-5-carboxamide, trifluoroacetate salt or N-[(3R)-4,4-difluoropiperidin-3-yl]-2- {5-[(3-ethoxypyridin-2-yl)oxy]pyridin-3- yl}pyrimidine-5-carboxamide, trifluoroacetate salt::US11065249, Example 15::US11065249, Example 16::US11471458, Example 15::US20230405002, Example 15

SMILES CCOc1cccnc1Oc1cncc(c1)-c1ncc(cn1)C(=O)N[C@H]1CNCCC1(F)F

InChI Key InChIKey=KRBLDXPHKCNGET-SFHVURJKSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 504502   

TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM504502(From first-eluting enantiomer of intermediate (see...)
Affinity DataIC50:  3.30E+3nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM504502(From first-eluting enantiomer of intermediate (see...)
Affinity DataIC50:  3.30E+3nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM504502(From first-eluting enantiomer of intermediate (see...)
Affinity DataIC50:  3.30E+3nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDiacylglycerol O-acyltransferase 2(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM504502(From first-eluting enantiomer of intermediate (see...)
Affinity DataIC50:  480nMAssay Description:For determination of IC50 values, the reactions were carried out in 384-well white polypropylene plates (Nunc) in a total volume of 20 μL. To 1 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent