BDBM50456439 CHEMBL4206925

SMILES CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@H]3CN(C)[C@]4(C)Cc5c(Br)[nH]c6cccc(C4=C3)c56)(O[C@@]2(O)C2CCCN2C1=O)C(C)C

InChI Key InChIKey=NZTOPQGTTUTKQB-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50456439   

TargetATP-dependent translocase ABCB1(Human)
Csir - Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50456439(CHEMBL4206925)
Affinity DataKi:  2.80E+3nMAssay Description:Inhibition of human MDR1 expressed in pig LLC-PK1 cells assessed as reduction in calcein-AM efflux preincubated for 30 mins followed by calcein-AM ad...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Csir - Indian Institute of Integrative Medicine

Curated by ChEMBL
LigandPNGBDBM50456439(CHEMBL4206925)
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of human MDR1 expressed in pig LLC-PK1 cells assessed as reduction in [3H]vinblastine efflux after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed