BindingDB BDBM50462709 CHEMBL4245507

BDBM50462709 CHEMBL4245507

SMILES O=C(Cc1cccc(OCCCN2CCNCC2)c1)Nc1nc(cs1)-c1ccncc1

InChI Key InChIKey=XLMFBNMLEHYJGT-UHFFFAOYSA-N

Data 2 KI 132 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 134 hits for monomerid = 50462709

Rho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

Ki: 51nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate by pyruvate kinase-lactate dehydrogen...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

cAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

Ki: >4.00E+3nMAssay Description:Inhibition of PKAalpha (1 to 351 residues) (unknown origin) using Leu-Arg-Arg-Ala-Ser-Leu-Gly as substrate by pyruvate kinase-lactate dehydrogenase c...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Mast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of KIT (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Dual specificity mitogen-activated protein kinase kinase 4(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of MKK4 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Insulin receptor(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of INSR (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Rho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: 8nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of SGK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase pim-1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of PIM1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Tyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of TYRO3 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase PLK1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Choline kinase alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of ChoK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Tyrosine-protein kinase BTK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

RAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of AKT1 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Macrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of FMS (unknown origin)More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Mitogen-activated protein kinase 13(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of P38delta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Ribosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of MSK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

Details Article PubMed

MAP kinase-activated protein kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of MAPKAPK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Interleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase PAK 3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of PAK3 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Ribosomal protein S6 kinase alpha-4(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of MSK2 (unknown origin)More data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Details Article PubMed

Protein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of PKCtheta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Proto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of ROS (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Ephrin type-B receptor 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of EPH-B2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase Chk2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of CHK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Aurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of AURA (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Tyrosine-protein kinase Yes(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of YES (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein kinase C alpha type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of PKCalpha (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase N2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of PRK2 (unknown origin)More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase D3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of PRKD3 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Ribosomal protein S6 kinase alpha-1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of RSK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Focal adhesion kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >9.00E+3nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Ephrin type-A receptor 4(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of EphA4 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase DCLK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of DCAMKL2 (unknown origin)More data for this Ligand-Target Pair

PDB KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Dual specificity protein kinase CLK3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of CLK3 (unknown origin)More data for this Ligand-Target Pair

PDB
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Citron Rho-interacting kinase(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of CIT (unknown origin)More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Cyclin-dependent kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >5.00E+3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Tyrosine-protein kinase ZAP-70(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >5.00E+3nMAssay Description:Inhibition of ZAP70 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Testis-specific serine/threonine-protein kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of TSSK2 (unknown origin)More data for this Ligand-Target Pair

KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Protein kinase C beta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of PKC-beta1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein kinase C epsilon type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of PKC-epsilon (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein kinase C beta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of PKCbeta2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein kinase C epsilon type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of PKCepsilon (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Protein kinase C gamma type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of PKCgamma (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase D1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of PRKD1 (unknown origin)More data for this Ligand-Target Pair

NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Serine/threonine-protein kinase D2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of PRKD2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

cAMP-dependent protein kinase catalytic subunit PRKX(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of PRKX (unknown origin)More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

Protein-tyrosine kinase 2-beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+3nMAssay Description:Inhibition of PYK2 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

Details Article PubMed

RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: >1.00E+4nMAssay Description:Inhibition of RAFc (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Details Article PubMed

Rho-associated protein kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50462709(CHEMBL4245507)

IC50: 2nMAssay Description:Inhibition of ROCK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Details Article PubMed

Displayed 1 to 50 (of 134 total ) | Next | Last >>

Filter my 134 hits

Targets 129▿
- Protein kinase C epsilon type 2
- Serine/threonine-protein kinase TBK1 2
- Protein kinase C beta type 2
- Rho-associated protein kinase 1 2
- Serine/threonine-protein kinase Sgk1 2
- Glycogen synthase kinase-3 beta 1
- Serine/threonine-protein kinase Nek2 1
- Serine/threonine-protein kinase Nek1 1
- Macrophage-stimulating protein receptor 1
- Choline kinase alpha 1
- Sphingosine kinase 1 1
- Serine/threonine-protein kinase PAK 1 1
- Protein kinase C theta type 1
- Serine/threonine-protein kinase PAK 2 1
- Serine/threonine-protein kinase PAK 3 1
- Tyrosine-protein kinase JAK3 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Proto-oncogene tyrosine-protein kinase receptor Ret 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Ceramide kinase 1
- Dual specificity mitogen-activated protein kinase kinase 7 1
- Dual specificity mitogen-activated protein kinase kinase 4 1
- Tyrosine-protein kinase ZAP-70 1
- Serine/threonine-protein kinase Sgk2 1
- Serine/threonine-protein kinase Sgk3 1
- Tyrosine-protein kinase BTK 1
- Ephrin type-A receptor 4 1
- Insulin-like growth factor 1 receptor 1
- Tyrosine-protein kinase Blk 1
- Epidermal growth factor receptor 1
- Inhibitor of nuclear factor kappa-B kinase subunit epsilon 1
- Ribosomal protein S6 kinase beta-1 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Tyrosine-protein kinase Lyn 1
- Focal adhesion kinase 1 1
- Cyclin-dependent kinase 2 1
- Cyclin-dependent kinase 1 1
- Ephrin type-B receptor 4 1
- Ephrin type-B receptor 2 1
- MAP kinase-activated protein kinase 2 1
- MAP kinase-activated protein kinase 3 1
- Death-associated protein kinase 1 1
- Tyrosine-protein kinase Fer 1
- Serine/threonine-protein kinase D2 1
- Serine/threonine-protein kinase D3 1
- Serine/threonine-protein kinase D1 1
- PAS domain-containing serine/threonine-protein kinase 1
- Casein kinase II subunit alpha/alpha 3/alpha'/beta 1
- Proto-oncogene tyrosine-protein kinase ROS 1
- Dual specificity tyrosine-phosphorylation-regulated kinase 1A 1
- Serine/threonine-protein kinase pim-1 1
- Cyclin-dependent kinase 5 1
- Serine/threonine-protein kinase pim-2 1
- Serine/threonine-protein kinase DCLK2 1
- Angiopoietin-1 receptor 1
- Mitogen-activated protein kinase kinase kinase kinase 2 1
- Testis-specific serine/threonine-protein kinase 2 1
- Mast/stem cell growth factor receptor Kit 1
- Mitogen-activated protein kinase kinase kinase kinase 4 1
- Mitogen-activated protein kinase 14 1
- Serine/threonine-protein kinase ATR 1
- Interleukin-1 receptor-associated kinase 4 1
- RAC-gamma serine/threonine-protein kinase 1
- Interleukin-1 receptor-associated kinase 1 1
- Mitogen-activated protein kinase kinase kinase 8 1
- Mitogen-activated protein kinase kinase kinase 7 1
- Tyrosine-protein kinase ABL1 1
- RAC-alpha serine/threonine-protein kinase 1
- Rho-associated protein kinase 2 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Mitogen-activated protein kinase 1 1
- 3-phosphoinositide-dependent protein kinase 1 1
- Tyrosine-protein kinase Lck 1
- Mitogen-activated protein kinase 3 1
- Serine/threonine-protein kinase 4 1
- Mitogen-activated protein kinase kinase kinase 14 1
- Mitogen-activated protein kinase 9 1
- Dual specificity protein kinase CLK3 1
- Protein-tyrosine kinase 2-beta 1
- Tyrosine-protein kinase Mer 1
- Serine/threonine-protein kinase N2 1
- Mitogen-activated protein kinase 8 1
- Ribosomal protein S6 kinase alpha-2 1
- Tyrosine-protein kinase SYK 1
- Ribosomal protein S6 kinase alpha-3 1
- Ribosomal protein S6 kinase alpha-1 1
- Phosphorylase b kinase gamma catalytic chain, liver/testis isoform 1
- Fibroblast growth factor receptor 4 1
- Aurora kinase B 1
- Vascular endothelial growth factor receptor 2 1
- Insulin receptor 1
- Vascular endothelial growth factor receptor 3 1
- Tyrosine-protein kinase HCK 1
- Aurora kinase A 1
- Fibroblast growth factor receptor 1 1
- Fibroblast growth factor receptor 2 1
- Aurora kinase C 1
- Fibroblast growth factor receptor 3 1
- Vascular endothelial growth factor receptor 1 1
- Serine/threonine-protein kinase PLK1 1
- Insulin receptor-related protein 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Mitogen-activated protein kinase 13 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Mitogen-activated protein kinase 12 1
- Tyrosine-protein kinase receptor TYRO3 1
- Mitogen-activated protein kinase 11 1
- RAC-beta serine/threonine-protein kinase 1
- Casein kinase I isoform alpha 1
- Protein kinase C gamma type 1
- Misshapen-like kinase 1 1
- Tyrosine-protein kinase Fyn 1
- Tyrosine-protein kinase CSK 1
- Macrophage colony-stimulating factor 1 receptor 1
- cAMP-dependent protein kinase catalytic subunit alpha 1
- Citron Rho-interacting kinase 1
- Ribosomal protein S6 kinase alpha-6 1
- Protein kinase C alpha type 1
- eIF-2-alpha kinase GCN2 1
- Ribosomal protein S6 kinase alpha-4 1
- Platelet-derived growth factor receptor alpha 1
- Ribosomal protein S6 kinase alpha-5 1
- Serine/threonine-protein kinase Chk2 1
- Serine/threonine-protein kinase MARK1 1
- Serine/threonine-protein kinase MARK2 1
- Serine/threonine-protein kinase Chk1 1
- cAMP-dependent protein kinase catalytic subunit PRKX 1
- Tyrosine-protein kinase Yes 1
- Mitogen-activated protein kinase kinase kinase 10 1
Publications 1▿
- Bioorg Med Chem Lett 28: 2616-2621 (2018) 134
Institutions 1▿
- Vertex Pharmaceuticals 134
Affinity: 2 to 1.0E+4 nM▿
- Ki 2
- IC50 132
- Affinity ≤ nM
Xtal structures: 0
Docked structures: 0
Catalog Cmpds: 0