BDBM504691 1-(2-fluoro-4-(5- (trifluoromethyl)- 1,2,4-oxadiazol-3- yl)phenyl)-5-(2- fluorophenyl) pyrrolidin-2-one::US11066396, Example 118::US11066396, Example 313

SMILES Fc1ccccc1C1CCC(=O)N1c1ccc(cc1F)-c1noc(n1)C(F)(F)F

InChI Key InChIKey=NPCHIHUPNUCSFR-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 504691   

TargetHistone deacetylase 6(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504691(1-(2-fluoro-4-(5- (trifluoromethyl)- 1,2,4-oxadiaz...)
Affinity DataIC50:  5.10nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504691(1-(2-fluoro-4-(5- (trifluoromethyl)- 1,2,4-oxadiaz...)
Affinity DataIC50:  570nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504691(1-(2-fluoro-4-(5- (trifluoromethyl)- 1,2,4-oxadiaz...)
Affinity DataIC50:  2.50E+3nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504691(1-(2-fluoro-4-(5- (trifluoromethyl)- 1,2,4-oxadiaz...)
Affinity DataIC50:  2.50E+3nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504691(1-(2-fluoro-4-(5- (trifluoromethyl)- 1,2,4-oxadiaz...)
Affinity DataIC50:  570nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 5(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504691(1-(2-fluoro-4-(5- (trifluoromethyl)- 1,2,4-oxadiaz...)
Affinity DataIC50:  130nMAssay Description:HDAC5 reagents: N-terminal GST tagged HDAC5 was purchased from BPS Bioscience [catalog #50045]. Assays were performed with buffer containing 20 mM HE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 6(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504691(1-(2-fluoro-4-(5- (trifluoromethyl)- 1,2,4-oxadiaz...)
Affinity DataIC50:  5.10nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent