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BDBM50481802 CHEBI:67727::FUROSPONGOLIDE::Furospongolide

SMILES: C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1

InChI Key: InChIKey=WCHKEOQZUQGPSS-ZTRBTYSCSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50481802   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50481802
PNG
(CHEBI:67727 | FUROSPONGOLIDE | Furospongolide)
Show SMILES C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1
Show InChI InChI=1S/C21H28O3/c1-17(8-4-10-19-12-13-23-15-19)6-3-7-18(2)9-5-11-20-14-21(22)24-16-20/h7-8,12-15H,3-6,9-11,16H2,1-2H3/b17-8+,18-7+
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n/an/a 2.90E+3n/an/an/an/an/an/a



University of Mississippi

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1 activation in human T47D cells after 16 hrs by pTK-HRE3-luciferase reporter gene assay


J Nat Prod 71: 1854-60 (2008)


Article DOI: 10.1021/np800342s
BindingDB Entry DOI: 10.7270/Q2BP05K9
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50481802
PNG
(CHEBI:67727 | FUROSPONGOLIDE | Furospongolide)
Show SMILES C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1
Show InChI InChI=1S/C21H28O3/c1-17(8-4-10-19-12-13-23-15-19)6-3-7-18(2)9-5-11-20-14-21(22)24-16-20/h7-8,12-15H,3-6,9-11,16H2,1-2H3/b17-8+,18-7+
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n/an/a 1.09E+4n/an/an/an/an/an/a



University of Mississippi

Curated by ChEMBL


Assay Description
Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells after 16 hrs by pTK-HRE3-luciferase reporter gene assay


J Nat Prod 71: 1854-60 (2008)


Article DOI: 10.1021/np800342s
BindingDB Entry DOI: 10.7270/Q2BP05K9
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50481802
PNG
(CHEBI:67727 | FUROSPONGOLIDE | Furospongolide)
Show SMILES C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1
Show InChI InChI=1S/C21H28O3/c1-17(8-4-10-19-12-13-23-15-19)6-3-7-18(2)9-5-11-20-14-21(22)24-16-20/h7-8,12-15H,3-6,9-11,16H2,1-2H3/b17-8+,18-7+
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Mississippi

Curated by ChEMBL


Assay Description
Inhibition of 1,10-phenanthroline-induced HIF1 activation in human PC3 cells after 16 hrs by pTK-HRE3-luciferase reporter gene assay


J Nat Prod 71: 1854-60 (2008)


Article DOI: 10.1021/np800342s
BindingDB Entry DOI: 10.7270/Q2BP05K9
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50481802
PNG
(CHEBI:67727 | FUROSPONGOLIDE | Furospongolide)
Show SMILES C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1
Show InChI InChI=1S/C21H28O3/c1-17(8-4-10-19-12-13-23-15-19)6-3-7-18(2)9-5-11-20-14-21(22)24-16-20/h7-8,12-15H,3-6,9-11,16H2,1-2H3/b17-8+,18-7+
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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Mississippi

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1 activation in human PC3 cells after 16 hrs by pTK-HRE3-luciferase reporter gene assay


J Nat Prod 71: 1854-60 (2008)


Article DOI: 10.1021/np800342s
BindingDB Entry DOI: 10.7270/Q2BP05K9
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50481802
PNG
(CHEBI:67727 | FUROSPONGOLIDE | Furospongolide)
Show SMILES C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1
Show InChI InChI=1S/C21H28O3/c1-17(8-4-10-19-12-13-23-15-19)6-3-7-18(2)9-5-11-20-14-21(22)24-16-20/h7-8,12-15H,3-6,9-11,16H2,1-2H3/b17-8+,18-7+
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Mississippi

Curated by ChEMBL


Assay Description
Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by reporter gene assay


J Nat Prod 71: 1854-60 (2008)


Article DOI: 10.1021/np800342s
BindingDB Entry DOI: 10.7270/Q2BP05K9
More data for this
Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha


(Homo sapiens (Human))
BDBM50481802
PNG
(CHEBI:67727 | FUROSPONGOLIDE | Furospongolide)
Show SMILES C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1
Show InChI InChI=1S/C21H28O3/c1-17(8-4-10-19-12-13-23-15-19)6-3-7-18(2)9-5-11-20-14-21(22)24-16-20/h7-8,12-15H,3-6,9-11,16H2,1-2H3/b17-8+,18-7+
PDB

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n/an/a>3.00E+4n/an/an/an/an/an/a



University of Mississippi

Curated by ChEMBL


Assay Description
Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by reporter gene assay


J Nat Prod 71: 1854-60 (2008)


Article DOI: 10.1021/np800342s
BindingDB Entry DOI: 10.7270/Q2BP05K9
More data for this
Ligand-Target Pair