BDBM50481802 CHEBI:67727::FUROSPONGOLIDE::Furospongolide

SMILES: C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1

InChI Key: InChIKey=WCHKEOQZUQGPSS-ZTRBTYSCSA-N

Data: 6 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50481802   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (Homo sapiens (Human))	BDBM50481802 (CHEBI:67727 | FUROSPONGOLIDE | Furospongolide) Show SMILES C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1 Show InChI InChI=1S/C21H28O3/c1-17(8-4-10-19-12-13-23-15-19)6-3-7-18(2)9-5-11-20-14-21(22)24-16-20/h7-8,12-15H,3-6,9-11,16H2,1-2H3/b17-8+,18-7+	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.90E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 activation in human T47D cells after 16 hrs by pTK-HRE3-luciferase reporter gene assay				J Nat Prod 71: 1854-60 (2008) Article DOI: 10.1021/np800342s BindingDB Entry DOI: 10.7270/Q2BP05K9
					More data for this Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (Homo sapiens (Human))	BDBM50481802 (CHEBI:67727 | FUROSPONGOLIDE | Furospongolide) Show SMILES C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1 Show InChI InChI=1S/C21H28O3/c1-17(8-4-10-19-12-13-23-15-19)6-3-7-18(2)9-5-11-20-14-21(22)24-16-20/h7-8,12-15H,3-6,9-11,16H2,1-2H3/b17-8+,18-7+	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.09E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi Curated by ChEMBL					Assay Description Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells after 16 hrs by pTK-HRE3-luciferase reporter gene assay				J Nat Prod 71: 1854-60 (2008) Article DOI: 10.1021/np800342s BindingDB Entry DOI: 10.7270/Q2BP05K9
					More data for this Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (Homo sapiens (Human))	BDBM50481802 (CHEBI:67727 | FUROSPONGOLIDE | Furospongolide) Show SMILES C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1 Show InChI InChI=1S/C21H28O3/c1-17(8-4-10-19-12-13-23-15-19)6-3-7-18(2)9-5-11-20-14-21(22)24-16-20/h7-8,12-15H,3-6,9-11,16H2,1-2H3/b17-8+,18-7+	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi Curated by ChEMBL					Assay Description Inhibition of 1,10-phenanthroline-induced HIF1 activation in human PC3 cells after 16 hrs by pTK-HRE3-luciferase reporter gene assay				J Nat Prod 71: 1854-60 (2008) Article DOI: 10.1021/np800342s BindingDB Entry DOI: 10.7270/Q2BP05K9
					More data for this Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (Homo sapiens (Human))	BDBM50481802 (CHEBI:67727 | FUROSPONGOLIDE | Furospongolide) Show SMILES C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1 Show InChI InChI=1S/C21H28O3/c1-17(8-4-10-19-12-13-23-15-19)6-3-7-18(2)9-5-11-20-14-21(22)24-16-20/h7-8,12-15H,3-6,9-11,16H2,1-2H3/b17-8+,18-7+	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 activation in human PC3 cells after 16 hrs by pTK-HRE3-luciferase reporter gene assay				J Nat Prod 71: 1854-60 (2008) Article DOI: 10.1021/np800342s BindingDB Entry DOI: 10.7270/Q2BP05K9
					More data for this Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (Homo sapiens (Human))	BDBM50481802 (CHEBI:67727 | FUROSPONGOLIDE | Furospongolide) Show SMILES C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1 Show InChI InChI=1S/C21H28O3/c1-17(8-4-10-19-12-13-23-15-19)6-3-7-18(2)9-5-11-20-14-21(22)24-16-20/h7-8,12-15H,3-6,9-11,16H2,1-2H3/b17-8+,18-7+	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi Curated by ChEMBL					Assay Description Inhibition of 1,10-phenanthroline-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by reporter gene assay				J Nat Prod 71: 1854-60 (2008) Article DOI: 10.1021/np800342s BindingDB Entry DOI: 10.7270/Q2BP05K9
					More data for this Ligand-Target Pair
Hypoxia inducible factors; HIF-1-alpha, HIF-2-alpha (Homo sapiens (Human))	BDBM50481802 (CHEBI:67727 | FUROSPONGOLIDE | Furospongolide) Show SMILES C\C(CCCC1=CC(=O)OC1)=C/CC\C(C)=C\CCc1ccoc1 Show InChI InChI=1S/C21H28O3/c1-17(8-4-10-19-12-13-23-15-19)6-3-7-18(2)9-5-11-20-14-21(22)24-16-20/h7-8,12-15H,3-6,9-11,16H2,1-2H3/b17-8+,18-7+	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Mississippi Curated by ChEMBL					Assay Description Inhibition of hypoxia-induced HIF1 activation in human T47D cells expressing pGL3 construct after 16 hrs by reporter gene assay				J Nat Prod 71: 1854-60 (2008) Article DOI: 10.1021/np800342s BindingDB Entry DOI: 10.7270/Q2BP05K9
					More data for this Ligand-Target Pair