BDBM505003 N-(3-fluoro- phenyl)-2- methyl-N- ({5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]pyridin- 2-yl} methyl) pyrimidine- 5-carbox-::US11066396, Example 401

SMILES Cc1ncc(cn1)C(=O)N(Cc1ccc(cn1)-c1noc(n1)C(F)(F)F)c1cccc(F)c1

InChI Key InChIKey=VKUOFKVSMACZNU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 505003   

TargetHistone deacetylase 6(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM505003(N-(3-fluoro- phenyl)-2- methyl-N- ({5-[5- (trifluo...)
Affinity DataIC50:  5.80nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM505003(N-(3-fluoro- phenyl)-2- methyl-N- ({5-[5- (trifluo...)
Affinity DataIC50:  3.30E+3nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM505003(N-(3-fluoro- phenyl)-2- methyl-N- ({5-[5- (trifluo...)
Affinity DataIC50:  290nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent