BDBM50502736 CHEMBL4472363::US11065231, Example 9

SMILES OC[C@H]1CC[C@H](CC1)n1c(NC(=O)c2cccc(c2)C(F)(F)F)nc2cc(CN3CCN(CC4CCN(CC4)c4ccc5C(=O)N(C6CCC(=O)NC6=O)C(=O)c5c4)CC3)ccc12

InChI Key InChIKey=JVXFYBJVHVGLKP-IYNWFLGGSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502736   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM50502736(CHEMBL4472363 | US11065231, Example 9)
Affinity DataIC50: <30nMAssay Description:A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM50502736(CHEMBL4472363 | US11065231, Example 9)
Affinity DataIC50: <30nMAssay Description:Inhibition of N-terminal GST-tagged human IRAK4 (2 to end residues) expressed in baculovirus infected Sf9 cells using Ser/Thr 7 peptide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed