BDBM505045 2-[({5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]pyridin- 2-yl} methyl) amino] pyridine- 4-carbox- amide::US11066396, Example 442

SMILES NC(=O)c1ccnc(NCc2ccc(cn2)-c2noc(n2)C(F)(F)F)c1

InChI Key InChIKey=NRBAVBGZDITUNV-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 505045   

TargetHistone deacetylase 6(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM505045(2-[({5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-...)
Affinity DataIC50:  7.30nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM505045(2-[({5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-...)
Affinity DataIC50:  750nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM505045(2-[({5-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-...)
Affinity DataIC50:  280nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent