BDBM50509365 CHEMBL4564337
SMILES COc1cc2c(c[nH]c2cc1Br)-c1cnc(o1)-c1ccc[nH]1
InChI Key InChIKey=XCOSAQGGGZDYJN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 36 hits for monomerid = 50509365
TargetBMP-2-inducible protein kinase(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 1.10E+3nMAssay Description:Binding affinity to wild-type human partial length BIKE (S34 to N329 residues) expressed in bacterial expression system by active-site directed compe...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 17A(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of DRAK1 (unknown origin) expressed in HEK293 cells by NanoLuc-luciferase reporter based intracellular ATP competitiveness assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibition of PIM1 (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 15(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of ERK8 (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of DYRK1A (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of PIM2 (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of PIM3 (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase kinase 2(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of GCK (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 11(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of MLK3 (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of Aurora A (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of Aurora B (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 17B(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 390nMAssay Description:Binding affinity to wild-type human full length DRAK2 (M1 to C372 residues) expressed in bacterial expression system by active-site directed competit...More data for this Ligand-Target Pair
TargetMyosin light chain kinase family member 4(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 430nMAssay Description:Binding affinity to wild-type human partial length MYLK4 (V79 to S380 residues) expressed in bacterial expression system by active-site directed comp...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 1.00E+3nMAssay Description:Binding affinity to wild-type human partial length JAK1 JH2 domain-pseudokinase expressed in bacterial expression system by active-site directed comp...More data for this Ligand-Target Pair
Target1-phosphatidylinositol 3-phosphate 5-kinase(Homo sapiens)
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 1.00E+3nMAssay Description:Binding affinity to wild-type human partial length PIKFYVE (F1512 to C2098 residues) expressed in mammalian expression system by active-site directed...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 3(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 1.70E+3nMAssay Description:Binding affinity to wild-type human partial length IRAK3 (V147 to E596 residues) expressed in bacterial expression system by active-site directed com...More data for this Ligand-Target Pair
TargetNon-receptor tyrosine-protein kinase TYK2(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 1.80E+3nMAssay Description:Binding affinity to wild-type human partial length TYK2 JH2 domain-pseudokinase expressed in mammalian expression system by active-site directed comp...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 36(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 2.70E+3nMAssay Description:Binding affinity to wild-type human partial length STK36 (M1 to T271 residues) expressed in bacterial expression system by active-site directed compe...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 17A(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 2.80E+3nMAssay Description:Binding affinity to wild-type human partial length DRAK1 (R32 to E363 residues) expressed in bacterial expression system by active-site directed comp...More data for this Ligand-Target Pair
TargetCasein kinase I isoform epsilon(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 3.30E+3nMAssay Description:Binding affinity to wild-type human full length CSNK1E (M1 to K416 residues) expressed in bacterial expression system by active-site directed competi...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-3(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 4.70E+3nMAssay Description:Binding affinity to wild-type human partial length PIM3 (G16 to A317 residues) expressed in bacterial expression system by active-site directed compe...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 8.90E+3nMAssay Description:Binding affinity to human partial length FLT3 N841I mutant (V592 to Y969 residues) expressed in bacterial expression system by active-site directed c...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 17A(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of Alexa Fluor 647-labeled ATP competitive kinase tracer binding to GST-tagged DRAK1 (unknown origin) by FRET based cell free ATP-competit...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 17B(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 9.80E+3nMAssay Description:Inhibition of Alexa Fluor 647-labeled ATP competitive kinase tracer binding to GST-tagged DRAK2 (unknown origin) by FRET based cell free ATP-competit...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 17B(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 500nMAssay Description:Inhibition of DRAK2 (unknown origin) expressed in HEK293 cells by NanoLuc-luciferase reporter based intracellular ATP competitiveness assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of TAK1 (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase kinase kinase 9(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of MLK1 (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase 35(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 1.30E+3nMAssay Description:Binding affinity to wild-type human partial length STK35 (G182 to A534 residues) expressed in bacterial expression system by active-site directed com...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase SIK3(Homo sapiens)
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of SIK3 (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of RIPK2 (unknown origin) by [33P]-ATP filter binding kinase assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase DCLK3(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 1.80E+3nMAssay Description:Binding affinity to wild-type human partial length DCAMKL3 (E140 to V628 residues) expressed in bacterial expression system by active-site directed c...More data for this Ligand-Target Pair
TargetCyclin-G-associated kinase(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 440nMAssay Description:Binding affinity to wild-type human partial length GAK (G13 to Y338 residues) expressed in bacterial expression system by active-site directed compet...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 1.20E+3nMAssay Description:Binding affinity to wild-type human partial length PIM1 (A15 to K313 residues) expressed in bacterial expression system by active-site directed compe...More data for this Ligand-Target Pair
TargetCitron Rho-interacting kinase(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 2.70E+3nMAssay Description:Binding affinity to wild-type human partial length CIT (M68 to E432 residues) expressed in bacterial expression system by active-site directed compet...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase RIO1(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 2.90E+3nMAssay Description:Binding affinity to wild-type human full length RIOK1 (M1 to K568 residues) expressed in bacterial expression system by active-site directed competit...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Uit - The Arctic University Of Norway
Curated by ChEMBL
Uit - The Arctic University Of Norway
Curated by ChEMBL
Affinity DataKd: 2.90E+3nMAssay Description:Binding affinity to wild-type human full length PIK4CB (M1 to M828 residues) expressed in mammalian expression system by active-site directed competi...More data for this Ligand-Target Pair