BDBM50528015 CHEMBL4514438::US11634404, Compound 70

SMILES COc1ccc(C(=O)N2CCN(CCOc3cccnc3)CC2)c(C)c1

InChI Key InChIKey=KARLVIFVRFFIOE-UHFFFAOYSA-N

Data  2 IC50  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50528015   

TargetD(3) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50528015(CHEMBL4514438 | US11634404, Compound 70)
Affinity DataEC50:  116nMAssay Description:Agonist activity at human D3R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
The United States of America, As Represented By The Secretary, Department of Health and Human Services

US Patent
LigandPNGBDBM50528015(CHEMBL4514438 | US11634404, Compound 70)
Affinity DataEC50:  116nMAssay Description:Compounds were tested for their ability to compete with the orthosteric radioligand [3H]methylspiperone for binding to the D3 DAR using stable HEK ce...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50528015(CHEMBL4514438 | US11634404, Compound 70)
Affinity DataEC50:  4.60E+3nMAssay Description:Agonist activity at human D2R expressed in CHOK1 cells assessed as induction of beta-arrestin recruitment measured after 90 mins by beta-galactosidas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50528015(CHEMBL4514438 | US11634404, Compound 70)
Affinity DataEC50:  4.60E+3nMAssay Description:For a secondary-screen and selectivity assays, DAR PathHunter βarrestin GPCR cell lines from DiscoverX (Fremont, Calif.) were used. In the D2 Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50528015(CHEMBL4514438 | US11634404, Compound 70)
Affinity DataIC50: 1.00E+5nMAssay Description:For a secondary-screen and selectivity assays, DAR PathHunter βarrestin GPCR cell lines from DiscoverX (Fremont, Calif.) were used. In the D2 Re...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2023
Entry Details
US Patent

TargetD(2) dopamine receptor(Human)
National Institute of Neurological Disorders and Stroke

Curated by ChEMBL
LigandPNGBDBM50528015(CHEMBL4514438 | US11634404, Compound 70)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human D2R expressed in CHOK1 cells assessed as inhibition of dopamine-induced beta-arrestin recruitment measured after 120 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed