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BDBM50531540 CHEBI:75998::GSK-1120212::GSK1120212::JTP 74057::JTP-74057::Mekinist::TMT-212::TMT212::TRAMETINIB::Tmt212::Trametinib

SMILES: CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O

InChI Key: InChIKey=LIRYPHYGHXZJBZ-UHFFFAOYSA-N

Data: 2 IC50  1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50531540   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Multidrug resistance protein 1/Multidrug resistance associated protein 1


(Homo sapiens (Human))
BDBM50531540
PNG
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Show SMILES CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O
Show InChI InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
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PC cid
PC sid
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n/an/an/an/a 247n/an/an/an/a



Rheinische Friedrich-Wilhelms-University of Bonn

Curated by ChEMBL


Assay Description
Inhibition of ABCB1 in human A2780/ADR cells assessed as potentiation of daunorubicin-induced cytotoxicity measured after 72 hrs by MTT assay


Eur J Med Chem 164: 193-213 (2019)


Article DOI: 10.1016/j.ejmech.2018.12.019
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase; MEK1/2


(Homo sapiens (Human))
BDBM50531540
PNG
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Show SMILES CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O
Show InChI InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
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n/an/a 15n/an/an/an/an/an/a



Mansoura University

Curated by ChEMBL


Assay Description
Inhibition of MEK2 (unknown origin)


Eur J Med Chem 168: 315-329 (2019)


Article DOI: 10.1016/j.ejmech.2019.02.050
More data for this
Ligand-Target Pair
Dual specificity mitogen-activated protein kinase kinase 1/Mitogen-activated protein kinase 1/RAF proto-oncogene serine/threonine-protein kinase


(Homo sapiens (Human))
BDBM50531540
PNG
(CHEBI:75998 | GSK-1120212 | GSK1120212 | JTP 74057...)
Show SMILES CC(=O)Nc1cccc(c1)-n1c2c(C)c(=O)n(C)c(Nc3ccc(I)cc3F)c2c(=O)n(C2CC2)c1=O
Show InChI InChI=1S/C26H23FIN5O4/c1-13-22-21(23(31(3)24(13)35)30-20-10-7-15(28)11-19(20)27)25(36)33(17-8-9-17)26(37)32(22)18-6-4-5-16(12-18)29-14(2)34/h4-7,10-12,17,30H,8-9H2,1-3H3,(H,29,34)
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PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.700n/an/an/an/an/an/a



Mansoura University

Curated by ChEMBL


Assay Description
Inhibition of MEK1 (unknown origin)


Eur J Med Chem 168: 315-329 (2019)


Article DOI: 10.1016/j.ejmech.2019.02.050
More data for this
Ligand-Target Pair