BDBM505417 (S)-8-chloro-6-(((1-cyclopropyl-1H- 1,2,3-triazol-4-yl)(6-(oxetan-3-yl)- 4,5,6,7-tetrahydrothieno[2,3-c]pyridin- 3-yl)methyl)amino)-4 -(neopentylamino)- quinoline-3-carbonitrile::US11066414, Compound 80::US11066414, Compound 81::US11066414, Compound 91

SMILES CC(C)(C)CNc1c(cnc2c(Cl)cc(NC(C3=CN(NN3)C3CC3)c3csc4CN(CCc34)C3COC3)cc12)C#N

InChI Key InChIKey=GDDLPRYSOFTDGY-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 505417   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM505417((S)-8-chloro-6-(((1-cyclopropyl-1H- 1,2,3-triazol-...)
Affinity DataIC50:  1nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM505417((S)-8-chloro-6-(((1-cyclopropyl-1H- 1,2,3-triazol-...)
Affinity DataIC50:  2nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM505417((S)-8-chloro-6-(((1-cyclopropyl-1H- 1,2,3-triazol-...)
Affinity DataIC50:  400nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent