BDBM50541814 CHEMBL4648848

SMILES C[C@@H]1CN([C@@H](C)CN1C(c1ccc(F)cc1)c1ccccc1F)c1cc(=O)n(C)c2ccc(nc12)C#N

InChI Key InChIKey=QBLJMEHOKNLCLR-VQSPDULUSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50541814   

TargetDiacylglycerol kinase alpha(Homo sapiens)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541814(CHEMBL4648848)
Affinity DataIC50:  580nMAssay Description:Inhibition of full-length C-terminal His6 tagged TVMV-pFBgate fused human DGKalpha expressed in baculovirus infected Sf9 insect cells using liposome ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase zeta(Homo sapiens)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541814(CHEMBL4648848)
Affinity DataIC50:  680nMAssay Description:Inhibition of DGKalpha/zeta in human whole blood assessed as induction of T-cell activation by measuring IFNgamma level preincubated for 1 hr followe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase zeta(Homo sapiens)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541814(CHEMBL4648848)
Affinity DataIC50:  26nMAssay Description:Inhibition of DGKA/DGKZ in human CD8 cells assessed as induction of CD8 activation by measuring IFNgamma level after 20 hrs by AlphaLISA assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDiacylglycerol kinase zeta(Homo sapiens)
Therachem Research Medilab

Curated by ChEMBL
LigandPNGBDBM50541814(CHEMBL4648848)
Affinity DataIC50:  330nMAssay Description:Inhibition of full length C-terminal His6tagged TVMV-His-pFBgate fused human DGK-zeta expressed in baculovirus infected Sf9 insect cells using liposo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed