BDBM50545569 CHEMBL4637997
SMILES Cn1nccc1-c1cc(ccc1[C@H]1CCc2cc(ccc12)S(=O)(=O)Nc1ncccn1)C(F)(F)F
InChI Key InChIKey=YMIUSSGKICXXJY-IBGZPJMESA-N
Data 10 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50545569
Affinity DataIC50: 71nMAssay Description:Use-dependent inhibition of human Nav1.7 expressed in HEK293 cells at 25 pulse 10 Hz frequency at -120 mV holding potential by manual patch clamp ass...More data for this Ligand-Target Pair
Affinity DataIC50: 8.10E+3nMAssay Description:Inhibition of human Nav1.7 at resting state expressed in HEK293 cells at -120 mV holding potential by 10 Hz single pulse protocol based manual patch ...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells assessed as V1/2 of slow inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair
Affinity DataIC50: 118nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells assessed as V1/2 of fast inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as V1/2 of fast inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair
Affinity DataIC50: 7.10E+3nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells assessed as V1/2 of inactivation at -120 mV holding potential by 10 Hz frequency two pulse proto...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20 mins follo...More data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibition of Nav1.7 (unknown origin) expressed in HEK293 cells assessed as reduction in veratridine-induced depolarization preincubated for 15 to 20...More data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells assessed as V1/2 of slow inactivation at 10 Hz frequency at -120 mV holding potential by single ...More data for this Ligand-Target Pair
Affinity DataIC50: 89nMAssay Description:Use-dependent inhibition of mouse Nav1.7 expressed in HEK293 cells at 25 pulse 10 Hz frequency at -120 mV holding potential by manual patch clamp ass...More data for this Ligand-Target Pair