BDBM50638470 Azenosertib::US20250304587, Compound ZnC3::ZN-C3::Zn-c3

SMILES CC[C@]1(CCc2c1nc(cc2)N3c4c(cnc(n4)Nc5ccc(cc5)N6CCN(CC6)C)C(=O)N3CC=C)O

InChI Key InChIKey=OXTSYWDBUVRXFF-UHFFFAOYSA-N

Data  3 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50638470   

TargetWee1-like protein kinase(Human)
Galixir

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50638470BDBM50638470(Azenosertib | Zn-c3 | ZN-C3 | US20250304587, Compo...)
Affinity DataIC50: 1.30nMAssay Description:Inhibition of Wee-1 (unknown origin) using Poly-Lys Tyr as substrate incubated for 60 mins in presence of ATP by ADP-Glo Kinase assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
6/6/2026
Entry Details
PubMedPDB3D3D Structure (crystal)
TargetWee1-like protein kinase(Human)
Galixir

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50638470BDBM50638470(Azenosertib | Zn-c3 | ZN-C3 | US20250304587, Compo...)
Affinity DataIC50: 55nMAssay Description:WEE1 (Thermo Fisher, Cat #PR7373A) protein in buffer (50 mM HEPES pH 7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% Brij-35) at 15 nM) in different concentration...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
1/19/2026
Entry Details
US Patent
PDB3D3D Structure (crystal)
TargetWee1-like protein kinase(Human)
Galixir

Curated by ChEMBL
LigandChemical structure of BindingDB Monomer ID 50638470BDBM50638470(Azenosertib | Zn-c3 | ZN-C3 | US20250304587, Compo...)
Affinity DataIC50: 567nMAssay Description:Inhibition of Wee1 in human U2OS cells assessed as reduction in CDK1 phosphorylation measured for 1 hr by Western blot analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In Depth
Date in BDB:
10/11/2025
Entry Details
PubMedPDB3D3D Structure (crystal)