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BDBM5880 2-Anilino-5-aryloxazole 44::N-[5-(Ethylsulfonyl)-2-methoxyphenyl]-5-(2 -fluoro-1,1 -biphenyl-3-yl)-1,3-oxazol-2-amine::N-[5-(ethanesulfonyl)-2-methoxyphenyl]-5-[3-(2-fluorophenyl)phenyl]-1,3-oxazol-2-amine

SMILES: CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccccc2F)c1

InChI Key: InChIKey=DOKIBWCVABZHOH-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 5880   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5880
PNG
(2-Anilino-5-aryloxazole 44 | N-[5-(Ethylsulfonyl)-...)
Show SMILES CCS(=O)(=O)c1ccc(OC)c(Nc2ncc(o2)-c2cccc(c2)-c2ccccc2F)c1
Show InChI InChI=1S/C24H21FN2O4S/c1-3-32(28,29)18-11-12-22(30-2)21(14-18)27-24-26-15-23(31-24)17-8-6-7-16(13-17)19-9-4-5-10-20(19)25/h4-15H,3H2,1-2H3,(H,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

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PC sid
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Similars

Article
PubMed
n/an/a 89n/an/an/an/an/an/a



GlaxoSmithKline



Assay Description
The assay was using baculovirus-expressed recombinant protein kinase purified as the intracellular domain fused by GST tag, interacting with biotinyl...


J Med Chem 48: 1610-9 (2005)


Article DOI: 10.1021/jm049538w
BindingDB Entry DOI: 10.7270/Q2FT8J85
More data for this
Ligand-Target Pair