BDBM6274 2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-8-(propan-2-yl)-7H,8H-pyrido[2,3-d]pyrimidin-7-one::8-Isopropyl-2-[4-(4-methylpiperazin-1-yl)phenylamino]-8H-pyrido[2,3-d]pyrimidin-7-one::N8 Pyrido[2,3-d]pyrimidin-7-one deriv. 66

SMILES CC(C)n1c2nc(Nc3ccc(cc3)N3CCN(C)CC3)ncc2ccc1=O

InChI Key InChIKey=FZMILJWYZFDXTP-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 6274   

TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1 [L188C](Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(8-Isopropyl-2-[4-(4-methylpiperazin-1-yl)phenylami...)
Affinity DataIC50: 32nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(8-Isopropyl-2-[4-(4-methylpiperazin-1-yl)phenylami...)
Affinity DataIC50: 58nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(8-Isopropyl-2-[4-(4-methylpiperazin-1-yl)phenylami...)
Affinity DataIC50: 70nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(8-Isopropyl-2-[4-(4-methylpiperazin-1-yl)phenylami...)
Affinity DataIC50: 270nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Human)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM6274(8-Isopropyl-2-[4-(4-methylpiperazin-1-yl)phenylami...)
Affinity DataIC50: 675nMAssay Description:The enzyme was assayed with substrate GST- retinoblastoma in the presence of 25 uM ATP/[gamma-32P] ATP. IC50 is the inhibitor concentration, which in...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2005
Entry Details Article
PubMed