BDBM7392 2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-dihydro-1H-indol-3-one::Indirubin::Indirubin derivative, 1::cid_5318433

SMILES: c1ccc2c(c1)/C(=C/3\C(=O)c4ccccc4N3)/C(=O)N2

InChI Key: InChIKey=CRDNMYFJWFXOCH-UHFFFAOYSA-N

Data: 25 IC50  9 EC50

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 34 hits for monomerid = 7392   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	600	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 beta (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5	n/a	n/a	n/a	n/a	n/a	n/a
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Cyclin-dependent kinase 11B (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2/G1/S-specific cyclin-E1 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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Glycogen synthase kinase-3 beta/[Tau protein] kinase (Pig)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
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Aryl hydrocarbon receptor (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	0.200	n/a	n/a	n/a	n/a
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Serine/threonine-protein kinase 17B (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
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GTPase KRas [1-37] (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 [99-307] (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	30
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Glycogen synthase kinase-3 beta (Porcine)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+3	n/a	n/a	n/a	n/a	n/a	30
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Cell division control protein 42 homolog (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cell division control protein 42 homolog (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
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Ras-related protein Rab-7a (Dog)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
GTPase KRas [1-37] (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
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Ras-related C3 botulinum toxin substrate 1 (Mouse)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Ras-related C3 botulinum toxin substrate 1 (Mouse)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B (Spiny starfish)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	7.2	30
TBA									Citation and Details
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Ras-related protein Rab-2A (Dog)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	n/a	n/a	3.00E+4	n/a	n/a	n/a	n/a
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					More data for this Ligand-Target Pair
Cyclin-dependent kinase 2 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	2.00E+3	n/a	n/a	n/a	n/a	8.0	22
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-A2/Cyclin-dependent kinase 2 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	7.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 4/G1/S-specific cyclin-D1 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
					More data for this Ligand-Target Pair
Cyclin-dependent kinase 5 activator 1 (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	5.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details
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Insulin-like growth factor 1 receptor (Human)	BDBM7392 (2-[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]-2,3-...) Show SMILES Show InChI	GoogleScholar	UniChem		n/a	n/a	>1.00E+6	n/a	n/a	n/a	n/a	n/a	n/a
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