BDBM7524 (2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-2-yl]amino}propan-1-ol::2,6,9-Trisubstituted purine deriv. 19

SMILES C[C@H](CO)Nc1nc(NCc2ccccc2)c2ncn(C(C)C)c2n1

InChI Key InChIKey=PEIHEIMZOKGNHC-CYBMUJFWSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 7524   

TargetCyclin-dependent kinase 1/G2/mitotic-specific cyclin-B(Marthasterias glacialis (starfish))
Institut Curie

LigandPNGBDBM7524((2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-...)
Affinity DataIC50:  850nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM7524((2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-...)
Affinity DataIC50:  850nMAssay Description:Inhibition of cyclin-dependent kinase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5(Homo sapiens (Human))
Institut Curie

Curated by ChEMBL
LigandPNGBDBM7524((2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-...)
Affinity DataIC50:  700nMAssay Description:Compound was tested for its inhibitory activity against cyclin-dependent kinase 5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Institut Curie

LigandPNGBDBM7524((2R)-2-{[6-(benzylamino)-9-(propan-2-yl)-9H-purin-...)
Affinity DataIC50:  700nMT: 2°CAssay Description:Kinase activities were assayed in buffers containing substrate, enzyme, and inhibitor at 30 °C in the presence of 15 uM ATP/ [gamma-32P] ATP. 32...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed