BDBM82020 1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xanthine)::1-Methylxanthine::CAS_80220::CHEMBL1250::NSC_80220

SMILES Cn1c(=O)[nH]c2nc[nH]c2c1=O

InChI Key InChIKey=SNXCZWZKBPOLIM-UHFFFAOYSA-N

Data  12 KI  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 82020   

TargetAdenosine receptor A2a/A2b(Homo sapiens (Human))
National Institutes Of Health

Curated by ChEMBL
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataKi:  1.90E+3nMAssay Description:Inhibition of the stimulation by 5'-(N-ethylcarbamoyl) adenosine of adenyl cyclase via adenosine A2 receptor in human platelet membranes.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition of adenosine stimulated accumulation of cyclic AMP at Adenosine A2 receptor of VA13 fibroblasts of ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataKi:  9.00E+3nMAssay Description:Binding of 1 nM [3H]-CHA to Adenosine A1 receptor of rat cerebral cortical membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by PDSP Ki Database
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataKi: >1.00E+4nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAdenosine receptor A1(GUINEA PIG)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataKi:  1.15E+4nMAssay Description:Affinity against adenosine A1 receptor in the brain membranes by the displacement of [3H]-CPX.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataKi:  1.70E+4nMAssay Description:Inhibition of 1 nM [3H]- N6- (phenylisopropyl) adenosine binding to Adenosine A1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataKi:  3.60E+4nMAssay Description:Binding affinity at Adenosine A1 receptor in rat brain cortical membrane using [3H]-N6-R-phenylisopropyladenosine (R-PIA) as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(Rattus norvegicus (rat))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataKi:  3.60E+4nMAssay Description:Binding affinity to A1 adenosine receptor from rat cortical membrane in presence of [3H]-R-(phenylisopropyl)-adenosineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a/A2b(Rattus norvegicus)
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataKi:  4.70E+4nMAssay Description:Binding affinity against Adenosine A2 receptor in rat striatal membranes using [3H]5'-(N-ethylcarboxamido)-adenosine (NECA) as the ligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(GUINEA PIG)
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataKi:  6.71E+4nMAssay Description:Affinity against adenosine A2 receptor in the brain membranes measured by the displacement of [3H]-CPXMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Hokuriku University

Curated by ChEMBL
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataKi:  1.63E+5nMAssay Description:Inhibition of c-AMP phosphodiesterase activity in guinea pig tracheal muscleMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Institute Of Biological Chemistry And The Genomics Research Center

Curated by ChEMBL
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataIC50: >2.00E+5nMAssay Description:Inhibition of human xanthine oxidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A2a(Homo sapiens (Human))
Warner-Lambert/Parke-Davis Pharmaceutical Research

Curated by PDSP Ki Database
LigandPNGBDBM82020(1-Methyl-3,9-dihydro-purine-2,6-dione(1-methyl xan...)
Affinity DataEC50:  7.59E+4nMAssay Description:Relexant activity on the spontaneous tone of isolated guinea pig tracheal ring chains.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed