BDBM8465 (2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylmethyl)sulfonamido]-3-methylbutanamide::BMCL16311 Compound 1a::CGS 27023::CGS 27023A::CHEMBL514138::hydroxamate analogue 1
SMILES COc1ccc(cc1)S(=O)(=O)N(Cc1cccnc1)[C@H](C(C)C)C(=O)NO
InChI Key InChIKey=BSIZUMJRKYHEBR-QGZVFWFLSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 178 hits for monomerid = 8465
Affinity DataKi: 1.27nM ΔG°: -12.0kcal/mole IC50: 1.90nMpH: 7.5 T: 22°CAssay Description:Test compounds were serially diluted in the assay buffer. In each well of a 96-well microtiter plate (Immunofluor B, Dynatech), the inhibitor solutio...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of human Matrix metalloprotease-9More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of matrix metalloprotease-9 (MMP-9).Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of human active MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 flu...More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of human matrix metalloprotease 9More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of human recombinant MMP9More data for this Ligand-Target Pair
Affinity DataKi: 8nMAssay Description:Inhibition of truncated gelatinase B (Matrix metalloprotease-9)More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibition of gelatinase-A (Matrix metalloprotease-2)More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibition of human active MMP9 using (7-methoxycoumarin-4-yl) acetyl pro-Leu-Gly-Leu-[3-(2,4-dinitrophenyl)-L-2,3-diamino-propionyl]-Ala-Arg-NH2 flu...More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibition of human recombinant MMP2More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibition of human matrix metalloprotease 2More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibition of matrix metalloprotease 2More data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Inhibition of matrix metalloprotease-2 (MMP-2).Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
Affinity DataKi: 33nMAssay Description:Inhibition of human matrix metalloprotease 1More data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 33nMAssay Description:Inhibition of matrix metalloprotease 1More data for this Ligand-Target Pair
Affinity DataKi: 33nMAssay Description:Inhibition of truncated collagenase-1 (Matrix metalloprotease-1)More data for this Ligand-Target Pair
Affinity DataKi: 33nMAssay Description:Inhibition of human recombinant MMP1More data for this Ligand-Target Pair
Affinity DataKi: 33nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
Affinity DataKi: 33nMAssay Description:Inhibition of human matrix metalloprotease-1More data for this Ligand-Target Pair
Affinity DataKi: 33nMAssay Description:Inhibition of collagenase-1 (Matrix metalloprotease-1)More data for this Ligand-Target Pair
Affinity DataKi: 33nMAssay Description:Inhibition of matrix metalloprotease-1 (MMP-1).Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Inhibition of human matrix metalloprotease-3More data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Inhibition of human recombinant MMP3More data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Stromelysin inhibitory activity is based on the hydrolysis of substance P by recombinant human stromelysin to generate a fragment, substance P 7-11, ...More data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Inhibition of matrix metalloprotease-3 (MMP-3).Checked by AuthorMore data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Inhibition of Matrix metalloprotease-3More data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Inhibition of truncated stromelysin (Matrix metalloprotease-3)More data for this Ligand-Target Pair
Affinity DataKi: 43nMAssay Description:Inhibition of matrix metalloprotease 3More data for this Ligand-Target Pair
Affinity DataKi: 7.80E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 9 by CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 8.60E+3nMAssay Description:Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataKi: 2.81E+5nMAssay Description:Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration methodMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMpH: 7.0 T: 22°CAssay Description:The assay was performed in a 96-well plate, each well contained substrate peptide, LF, and the test compound. The C-terminally fluorophore of substra...More data for this Ligand-Target Pair
Affinity DatapH: 7.5 T: 30°CAssay Description:The recombinant Agg-1 proteins pretreated with the various concentrations of the compound for 10 to 15 min. The reaction was initiated by addition of...More data for this Ligand-Target Pair
Affinity DataIC50: 42nMT: 25°CAssay Description:Test compounds were serially diluted in deep well plates, and an aliquot of the inhibitor solutions was transferred to a Biomek deep well plate conta...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMT: 25°CAssay Description:Test compounds were serially diluted in deep well plates, and an aliquot of the inhibitor solutions was transferred to a Biomek deep well plate conta...More data for this Ligand-Target Pair
Affinity DataIC50: 6.80nMT: 25°CAssay Description:Test compounds were serially diluted in deep well plates, and an aliquot of the inhibitor solutions was transferred to a Biomek deep well plate conta...More data for this Ligand-Target Pair
Affinity DataIC50: 9.10nMAssay Description:Inhibition of human matrix metalloprotease 2More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of human matrix metalloprotease 1More data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of ADAM17 in human A2774 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of ADAM17 in human SKOV3 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Inhibition of ADAM17 in human MCF7 cells assessed as inhibition of pervanadate-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Inhibition of ADAM17 in human MDA-MB-468 cells assessed as inhibition of EGF-induced sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of ADAM17 in human GI-CA-N cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant MMP14 by fluorometric assayMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of ADAM17 in human A2774 cells assessed as inhibition of constitutive sALCAM release by ELISAMore data for this Ligand-Target Pair
TargetDisintegrin and metalloproteinase domain-containing protein 17(Human)
University of Pisa
Curated by ChEMBL
University of Pisa
Curated by ChEMBL
Affinity DataIC50: 160nMAssay Description:Inhibition of human recombinant ADAM17 by fluorometric assayMore data for this Ligand-Target Pair