BDBM9460 3-(4-aminophenyl)-3-ethyl-piperidine-2,6-dione::3-(4-aminophenyl)-3-ethylpiperidine-2,6-dione::Aminoglutethimide AG, 4::CHEMBL488::Cytadren::Elipten::aminoglutethimide (AG)
SMILES CCC1(CCC(=O)NC1=O)c1ccc(N)cc1
InChI Key InChIKey=ROBVIMPUHSLWNV-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 64 hits for monomerid = 9460
Affinity DataKi: 470nMAssay Description:Competitive inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataKi: 600nMAssay Description:Binding affinity was measured on Cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataKi: 600nMAssay Description:Inhibitory activity against human placental cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataKi: 600nMAssay Description:Inhibitory constant (Ki) for Cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataKi: 680nMAssay Description:Inhibition of Cytochrome P450 19A1 against testosterone at 1.5 uM (Km=0.13 uM)More data for this Ligand-Target Pair
Affinity DataKi: 1.41E+3nM ΔG°: -8.30kcal/mole IC50: 2.80E+3nMpH: 7.0 T: 2°CAssay Description:Inhibition of human placental aromatase was determined by monitoring the amount of 3H2O released as the enzyme converts [1beta-3H]androst-4-ene-3,17-...More data for this Ligand-Target Pair
Affinity DataKi: 1.41E+3nM ΔG°: -8.30kcal/mole IC50: 2.80E+3nMpH: 7.0 T: 2°CAssay Description:Inhibition of human placental aromatase was determined by monitoring the amount of 3H2O released as the enzyme converts [1beta-3H]androst-4-ene-3,17-...More data for this Ligand-Target Pair
Affinity DataKi: 1.41E+3nM ΔG°: -8.30kcal/mole IC50: 2.80E+3nMpH: 7.0 T: 2°CAssay Description:Inhibition of human placental aromatase was determined by monitoring the amount of 3H2O released as the enzyme converts [1beta-3H]androst-4-ene-3,17-...More data for this Ligand-Target Pair
Affinity DataKi: 1.80E+3nMAssay Description:Inhibition of human placental cytochrome P450 19A1 with testosteroneMore data for this Ligand-Target Pair
Affinity DataKi: 1.80E+3nMAssay Description:Inhibition of human placental cytochrome P450 19A1 with androstenedioneMore data for this Ligand-Target Pair
Affinity DataKi: 4.10E+3nMAssay Description:Inhibition of human aromatase extracted from placental microsomes using [1,2-3H]androstenedione as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+4nMAssay Description:Inhibition of rat ovarian Cytochrome P450 19AMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+4nMAssay Description:In vitro inhibitory concentration against human placental Cytochrome P450 19A was determined using [1beta,2beta-3H]testosterone as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:In vitro inhibition of cytochrome P450 19A1 AromataseMore data for this Ligand-Target Pair
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of Cytochrome P450 19A1 against Androstenedione at 0.25 uM (Km=55 nM)More data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Rattus norvegicus)
Universität des Saarlandes
Curated by ChEMBL
Universität des Saarlandes
Curated by ChEMBL
Affinity DataIC50: 5.00E+4nMAssay Description:In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slicesMore data for this Ligand-Target Pair
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory activity against human placental cytochrome P450 19A1More data for this Ligand-Target Pair
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Bos taurus (Bovine))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of bovine desmolase, cytochrome P450 11A1More data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+4nMAssay Description:Inhibition of human placental aromataseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of Human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 6.20E+3nMAssay Description:In vitro inhibition of rat ovarian microsomal Cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:In vitro inhibition of human placental Cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of human placental aromatase, cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of human placental microsome cytochrome P450 19A1 aromataseMore data for this Ligand-Target Pair
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of aromatase from human placental microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+3nMAssay Description:In vitro inhibition of [1,2,6,7-3H]-androstenedione binding to human placental microsome cytochrome P450 19A1More data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of aromatase activity in human placental microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.85E+4nMAssay Description:Inhibition of cytochrome P450 19A1 of human placental microsomes with [1beta,2beta-3H]testosteroneMore data for this Ligand-Target Pair
Affinity DataIC50: 6.40E+3nMAssay Description:Inhibition of HIF-1alpha in human Hep3B cells cotransfected with pGL3-HRE-luciferase plasmid after 24 hrs by dual-luciferase reporter assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.98E+4nMAssay Description:Inhibition of CYP19More data for this Ligand-Target Pair
Affinity DataIC50: 2.98E+4nMAssay Description:Inhibition of aromatase in human placental microsomesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aromatase in human breast tumorMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human aromatase transfected in human MCF7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human placental aromatase assessed as conversion of [1beta-3H]androstenedione to [1beta-3H]estrone after 20 mins by liquid scintillatio...More data for this Ligand-Target Pair
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of aromatase in human placental microsomes assessed as inhibition of aromatization of [1,2,6,7-3H] androstenedione by flow scintillation a...More data for this Ligand-Target Pair
Affinity DataEC50: 260nMAssay Description:In vitro inhibition of cytochrome P450 19A1 by rat ovarian microsomes incubated with [3H]androstenedione and NADPH-generating system.More data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+4nMAssay Description:Inhibition of Cytochrome P450 19A1 in human placentaMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:In vitro inhibition of aldosterone production in rat adrenal tissueMore data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Inhibition of human aromataseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.07E+6nMAssay Description:Inhibition of Cytochrome P450 19A1 activity 6 hr after oral administrationMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human placental microsome CYP19More data for this Ligand-Target Pair
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Homo sapiens (Human))
Ciba-Geigy Corporation
Curated by ChEMBL
Ciba-Geigy Corporation
Curated by ChEMBL
Affinity DataIC50: 8.00E+4nMAssay Description:In vitro inhibition of progesterone production in hamster ovarian tissueMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Rattus norvegicus)
Universität des Saarlandes
Curated by ChEMBL
Universität des Saarlandes
Curated by ChEMBL
Affinity DataIC50: 1.10E+5nMAssay Description:In vitro inhibition of aldosterone production in rat adrenal tissueMore data for this Ligand-Target Pair
TargetCholesterol side-chain cleavage enzyme, mitochondrial(Bos taurus (Bovine))
TBA
Curated by ChEMBL
TBA
Curated by ChEMBL
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of bovine adrenal desmolaseMore data for this Ligand-Target Pair
TargetCytochrome P450 11B2, mitochondrial(Rattus norvegicus)
Universität des Saarlandes
Curated by ChEMBL
Universität des Saarlandes
Curated by ChEMBL
Affinity DataIC50: 8.00E+4nMAssay Description:In vitro inhibition of ACTH-stimulated aldosterone biosynthesis in rat adrenal slicesMore data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+4nMAssay Description:Concentration of the compound inhibiting AromataseMore data for this Ligand-Target Pair
Affinity DataIC50: 6.13E+3nMAssay Description:Inhibition of Cytochrome P450 19A1 against testosterone at 1.5 microM (Km=0.13 uM)More data for this Ligand-Target Pair
Affinity DataIC50: 1.85E+4nMT: 2°CAssay Description:The classical 3H2O assay was used to measure the effect of the inhibitor compounds on aromatase activity using human placental microsomes.More data for this Ligand-Target Pair
Affinity DataIC50: 270nMAssay Description:Aromatase inhibition was quantified by measuring the fluorescent intensity of fluorescein, the hydrolysis product of dibenzylfluorescein (DBF), by ar...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human placental cytochrome P450 19A1 with androstenedioneMore data for this Ligand-Target Pair