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Found 1817 with Last Name = 'yuan' and Initial = 's'
TargetHistamine H3 receptor(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50247053(1-(3-(3-(4-chlorophenyl)propoxy)propyl)piperidine ...)
Affinity DataKi:  0.160nMAssay Description:Antagonist activity at recombinant human H3 receptor expressed in CHO-K1 cell membranes incubated for 60 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50556205(BAY 1841788 | BAY-1841788 | BAY1841788 | Darolutam...)
Affinity DataKi:  11nMAssay Description:Inhibition of androgen receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50051436((2R,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy...)
Affinity DataKi:  39nMAssay Description:Binding affinity of the compound towards purified recombinant human placental S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50051435(5'-Dehydroadenosine | 5'-deoxy-5'-oxoadenosine | 9...)
Affinity DataKi:  39nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50051435(5'-Dehydroadenosine | 5'-deoxy-5'-oxoadenosine | 9...)
Affinity DataKi:  39nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50051435(5'-Dehydroadenosine | 5'-deoxy-5'-oxoadenosine | 9...)
Affinity DataKi:  43nMAssay Description:Binding affinity of the compound towards purified recombinant human placental S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50051436((2R,3S,4R,5R)-5-(6-Amino-purin-9-yl)-3,4-dihydroxy...)
Affinity DataKi:  43nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50425732(ENZALUTAMIDE | US10053433, FC 4.129 | US10806720, ...)
Affinity DataKi:  86nMAssay Description:Inhibition of androgen receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAndrogen receptor(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50094975(956104-40-8 | ARN-509 | JNJ-56021927 | US10053433,...)
Affinity DataKi:  93nMAssay Description:Inhibition of androgen receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369258(CHEMBL606276)
Affinity DataKi:  95nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50368896(CHEMBL608056)
Affinity DataKi:  96nMAssay Description:Tested for kinetic constant for the inhibition of recombinant human placental S-Adenosyl-L-homocysteine HydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369257(CHEMBL605902)
Affinity DataKi:  101nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50407233(CHEMBL2092790)
Affinity DataKi:  110nMAssay Description:Tested for kinetic constant for the inhibition of recombinant human placental S-Adenosyl-L-homocysteine HydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369255(CHEMBL605900)
Affinity DataKi:  111nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50407232(CHEMBL2092789)
Affinity DataKi:  134nMAssay Description:Tested for kinetic constant for the inhibition of recombinant human placental S-Adenosyl-L-homocysteine HydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50408149(CHEMBL2093112)
Affinity DataKi:  224nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50051438((1R,2R,3S,4R)-4-(6-Amino-purin-9-yl)-2,3-dihydroxy...)
Affinity DataKi:  273nMAssay Description:Binding affinity of the compound towards purified recombinant human placental S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369159(CHEMBL610148)
Affinity DataKi:  320nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369158(CHEMBL612224)
Affinity DataKi:  360nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50331791((2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydr...)
Affinity DataKi:  410nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369156(CHEMBL608072)
Affinity DataKi:  570nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369161(CHEMBL610383)
Affinity DataKi:  570nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50408148(CHEMBL1288616)
Affinity DataKi:  670nMAssay Description:concentration dependent inhibition of S-Adenosyl-homocysteine hydrolase was determined by Kitz and Wilson methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50368898(CHEMBL604208)
Affinity DataKi:  681nMAssay Description:Tested for kinetic constant for the inhibition of recombinant human placental S-Adenosyl-L-homocysteine HydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369162(CHEMBL610384)
Affinity DataKi:  710nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369157(CHEMBL608915)
Affinity DataKi:  770nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369393(CHEMBL608312)
Affinity DataKi:  1.10E+3nMAssay Description:Kinetic constant calculated from the pseudo-first-order rate constant(k app) for S-adenosyl-homocysteine hydrolase inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50368895(CHEMBL610125)
Affinity DataKi:  1.30E+3nMAssay Description:Tested for kinetic constant for the inhibition of recombinant human placental S-Adenosyl-L-homocysteine HydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369160(CHEMBL608025)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369392(CHEMBL608911)
Affinity DataKi:  1.70E+3nMAssay Description:Kinetic constant calculated from the pseudo-first-order rate constant(k app) for S-adenosyl-homocysteine hydrolase inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50407975(CHEMBL519809)
Affinity DataKi:  1.93E+3nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50367376(CHEMBL605866)
Affinity DataKi:  2.60E+3nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369380(CHEMBL606502)
Affinity DataKi:  3.10E+3nMAssay Description:The kinetic constant for inhibition of S-adenosyl-homocysteine hydrolase by the compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369381(CHEMBL612194)
Affinity DataKi:  3.60E+3nMAssay Description:The kinetic constant for inhibition of S-adenosyl-homocysteine hydrolase by the compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369394(CHEMBL608943)
Affinity DataKi:  3.80E+3nMAssay Description:Kinetic constant calculated from the pseudo-first-order rate constant(k app) for S-adenosyl-homocysteine hydrolase inactivationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369379(CHEMBL607755)
Affinity DataKi:  3.90E+3nMAssay Description:The kinetic constant for inhibition of S-adenosyl-homocysteine hydrolase by the compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50051437((1S,2R,3S,4R)-4-(6-Amino-purin-9-yl)-2,3-dihydroxy...)
Affinity DataKi:  4.50E+3nMAssay Description:Binding affinity of the compound towards purified recombinant human placental S-adenosyl-L-homocysteine hydrolaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369155(CHEMBL609186)
Affinity DataKi:  1.98E+4nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM85777(B-NECA)
Affinity DataKi:  4.34E+4nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosylhomocysteinase(Homo sapiens (Human))
University Of Kansas

Curated by ChEMBL
LigandPNGBDBM50369163(CHEMBL610101)
Affinity DataKi:  4.85E+4nMAssay Description:Inhibition of S-adenosyl-L-homocysteine hydrolase, inactivation rate constant.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81917(BX-2819)
Affinity DataIC50:  0.0400nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81916(lspropyl analog, 5)
Affinity DataIC50:  0.100nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81914(Ethyl carbamate analog, 3)
Affinity DataIC50:  0.100nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50458169(Avagacestat | BMS 708163 | BMS-708163 | BMS-708163...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81915(Ethyl analog, 4)
Affinity DataIC50:  0.200nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50492082(CHEMBL2396959)
Affinity DataIC50:  0.220nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM549581((3R*,4R*)-1-Cyclohexyl-4-{[5-(2,4-difluoro-phenyl)...)
Affinity DataIC50:  0.300nMAssay Description:Tango CXCR7-bla U2OS cells are detached from culture dishes with 0.05% trypsin-EDTA and collected in growing medium (McCoy's 5A 90% (v/v), dialyz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPresenilin-1(Homo sapiens (Human))
Elan Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50492094(CHEMBL2396964)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of gamma-secretase in human IMR32 cell membrane using APP as substrate after 2 hrs by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHeat shock protein HSP 90-alpha(Homo sapiens (Human))
Bayer Healthcare

LigandPNGBDBM81912(DC23 | Resorcinol analog, 1)
Affinity DataIC50:  0.300nMpH: 7.4Assay Description:To assess the affinity of compounds binding to Hsp90, we measured their ability to compete with the binding of a fluorescent analog of GA (GM-Bodipy)...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAtypical chemokine receptor 3(Homo sapiens (Human))
Idorsia Pharmaceuticals

US Patent
LigandPNGBDBM549988((3S,4S)-1-Cyclopropylmethyl-4-{[5-(2,4-difluoro-ph...)
Affinity DataIC50:  0.300nMAssay Description:Tango CXCR7-bla U2OS cells are detached from culture dishes with 0.05% trypsin-EDTA and collected in growing medium (McCoy's 5A 90% (v/v), dialyz...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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