Simple Search Results

Search and Browse
- Target
- Compound
- Special tools
- Citation
- Special Data Sets
- Other Databases
  - PDB 85% 100% Seq ID
  - UniProtKB/Swiss-Prot
  - UniProtKB/TrEMBL
  - PubMed
Download
- All Compounds & Data
- Target Names &
  - Ki IC50 Kd EC50
  - ΔG° ΔH° -TΔS°
Enter Data

Simple Search Results

Query String: LecB

lecb

BDBM103986 LecB Inhibitor Triazoles 2d
BDBM103987 LecB Inhibitor Triazoles 2e
BDBM103989 LecB Inhibitor Triazoles 2g
BDBM103996 LecB Inhibitor Amides 4g
BDBM103997 LecB Inhibitor Amines 3a
BDBM103998 LecB Inhibitor Amines 3b
BDBM103999 LecB Inhibitor Amines 3c
BDBM104002 LecB Inhibitor Sulfonamides 5a
BDBM104008 LecB Inhibitor Sulfonamides 5g
LecB Inhibitor Amides 4a BDBM103990
LecB Inhibitor Amides 4b BDBM103991
LecB Inhibitor Amides 4c BDBM103992
LecB Inhibitor Amides 4d BDBM103993
LecB Inhibitor Amides 4e BDBM103994
LecB Inhibitor Amides 4f BDBM103995
LecB Inhibitor Amines 3d BDBM104000
LecB Inhibitor Amines 3e BDBM104001
LecB Inhibitor Compound 1 BDBM103981
LecB Inhibitor Ligand 6 BDBM103982
LecB Inhibitor Sulfonamides 5b BDBM104003
LecB Inhibitor Sulfonamides 5c BDBM104004
LecB Inhibitor Sulfonamides 5d BDBM104005
LecB Inhibitor Sulfonamides 5e BDBM104006
LecB Inhibitor Triazoles 2a BDBM103983
LecB Inhibitor Triazoles 2b BDBM103984
LecB Inhibitor Triazoles 2c BDBM103985

Hauck, D; Joachim, I; Frommeyer, B; Varrot, A; Philipp, B; M�ller, HM; Möller, A; Exner, TE; Titz, A Discovery of two classes of potent glycomimetic inhibitors of Pseudomonas aeruginosa LecB with distinct binding modes. ACS Chem Biol 8: 1775-84 (2013)

Fluorescence Polarization Assay 10uL serial dilutions (10mM to 128uM) of testing compounds in TBS/Ca in triplicates were added to 20uL of a stock solution of LecB (225nM) and reporter ligand (1.5nM) in TBS/Ca. The microtiter plates were centrifuged at 800rpm for 1 min at 23 degrees Celsius and incubated for 6h at RT. The fluorescence was measured using a Tecan INFINITE F500 plate reader with excitation filters at 485nm and emission filters at 535nm in black 384-well microtiter plates.