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Compile Data Set for Download or QSAR

Found 30 hits Enz. Inhib. hit(s) with all data for entry = 50030846   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302574
PNG
(CHEMBL576049 | N-butyl-N-ethyl-1-mesityl-3,6-dimet...)
Show SMILES CCCCN(CC)c1nc(C)nc2n(nc(C)c12)-c1c(C)cc(C)cc1C
Show InChI InChI=1S/C22H31N5/c1-8-10-11-26(9-2)21-19-17(6)25-27(22(19)24-18(7)23-21)20-15(4)12-14(3)13-16(20)5/h12-13H,8-11H2,1-7H3
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9n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302593
PNG
(1-(4-methoxy-2-methylphenyl)-N-(2-methoxyethyl)-3,...)
Show SMILES CCCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C21H29N5O2/c1-7-10-25(11-12-27-5)20-19-15(3)24-26(21(19)23-16(4)22-20)18-9-8-17(28-6)13-14(18)2/h8-9,13H,7,10-12H2,1-6H3
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13n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302599
PNG
(1-(2,6-dimethoxypyridin-3-yl)-N-(2-methoxyethyl)-3...)
Show SMILES CCCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1ccc(OC)nc1OC
Show InChI InChI=1S/C20H28N6O3/c1-7-10-25(11-12-27-4)18-17-13(2)24-26(19(17)22-14(3)21-18)15-8-9-16(28-5)23-20(15)29-6/h8-9H,7,10-12H2,1-6H3
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17n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302573
PNG
(CHEMBL569666 | N-(heptan-4-yl)-1-(4-methoxy-2-meth...)
Show SMILES CCCC(CCC)Nc1nc(C)nc2n(ncc12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C21H29N5O/c1-6-8-16(9-7-2)25-20-18-13-22-26(21(18)24-15(4)23-20)19-11-10-17(27-5)12-14(19)3/h10-13,16H,6-9H2,1-5H3,(H,23,24,25)
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32n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302582
PNG
(CHEMBL566279 | N-(heptan-4-yl)-1-(4-methoxy-2-meth...)
Show SMILES CCCC(CCC)Nc1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C22H31N5O/c1-7-9-17(10-8-2)25-21-20-15(4)26-27(22(20)24-16(5)23-21)19-12-11-18(28-6)13-14(19)3/h11-13,17H,7-10H2,1-6H3,(H,23,24,25)
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35n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302581
PNG
(1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-N-(penta...)
Show SMILES CCC(CC)Nc1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C20H27N5O/c1-7-15(8-2)23-19-18-13(4)24-25(20(18)22-14(5)21-19)17-10-9-16(26-6)11-12(17)3/h9-11,15H,7-8H2,1-6H3,(H,21,22,23)
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42n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302598
PNG
(1-(6-methoxy-2-methylpyridin-3-yl)-N-(2-methoxyeth...)
Show SMILES CCCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1ccc(OC)nc1C
Show InChI InChI=1S/C20H28N6O2/c1-7-10-25(11-12-27-5)19-18-14(3)24-26(20(18)23-15(4)22-19)16-8-9-17(28-6)21-13(16)2/h8-9H,7,10-12H2,1-6H3
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43n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302594
PNG
(1-(2,4-dimethoxyphenyl)-N-(2-methoxyethyl)-3,6-dim...)
Show SMILES CCCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1OC
Show InChI InChI=1S/C21H29N5O3/c1-7-10-25(11-12-27-4)20-19-14(2)24-26(21(19)23-15(3)22-20)17-9-8-16(28-5)13-18(17)29-6/h8-9,13H,7,10-12H2,1-6H3
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74n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302577
PNG
((2R)-2-(1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-...)
Show SMILES CCC[C@H](CO)Nc1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C20H27N5O2/c1-6-7-15(11-26)23-19-18-13(3)24-25(20(18)22-14(4)21-19)17-9-8-16(27-5)10-12(17)2/h8-10,15,26H,6-7,11H2,1-5H3,(H,21,22,23)/t15-/m1/s1
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76n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302589
PNG
(CHEMBL568188 | N-(1-(4-methoxy-2-methylphenyl)-3,6...)
Show SMILES CCCNCc1noc(Nc2nc(C)nc3n(nc(C)c23)-c2ccc(OC)cc2C)n1
Show InChI InChI=1S/C21H26N8O2/c1-6-9-22-11-17-25-21(31-28-17)26-19-18-13(3)27-29(20(18)24-14(4)23-19)16-8-7-15(30-5)10-12(16)2/h7-8,10,22H,6,9,11H2,1-5H3,(H,23,24,25,26,28)
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84n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302584
PNG
(1-(4-methoxy-2-methylphenyl)-6-methyl-N-(pentan-3-...)
Show SMILES CCC(CC)Nc1nc(C)nc2n(ncc12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C19H25N5O/c1-6-14(7-2)23-18-16-11-20-24(19(16)22-13(4)21-18)17-9-8-15(25-5)10-12(17)3/h8-11,14H,6-7H2,1-5H3,(H,21,22,23)
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85n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302595
PNG
(4-(4-((2-methoxyethyl)(propyl)amino)-3,6-dimethyl-...)
Show SMILES CCCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1ccc(cc1C)C#N
Show InChI InChI=1S/C21H26N6O/c1-6-9-26(10-11-28-5)20-19-15(3)25-27(21(19)24-16(4)23-20)18-8-7-17(13-22)12-14(18)2/h7-8,12H,6,9-11H2,1-5H3
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101n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302602
PNG
(CHEMBL567383 | N-ethyl-1-(4-methoxy-2-methylphenyl...)
Show SMILES CCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C20H27N5O2/c1-7-24(10-11-26-5)19-18-14(3)23-25(20(18)22-15(4)21-19)17-9-8-16(27-6)12-13(17)2/h8-9,12H,7,10-11H2,1-6H3
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117n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302590
PNG
(CHEMBL566938 | N-(1-(4-methoxy-2-methylphenyl)-3,6...)
Show SMILES CCCNCc1nc(Nc2nc(C)nc3n(nc(C)c23)-c2ccc(OC)cc2C)no1
Show InChI InChI=1S/C21H26N8O2/c1-6-9-22-11-17-25-21(28-31-17)26-19-18-13(3)27-29(20(18)24-14(4)23-19)16-8-7-15(30-5)10-12(16)2/h7-8,10,22H,6,9,11H2,1-5H3,(H,23,24,26,28)
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124n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302586
PNG
(2-((1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-1H-p...)
Show SMILES CCCN(CCO)c1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C20H27N5O2/c1-6-9-24(10-11-26)19-18-14(3)23-25(20(18)22-15(4)21-19)17-8-7-16(27-5)12-13(17)2/h7-8,12,26H,6,9-11H2,1-5H3
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129n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302583
PNG
(1-(4-methoxy-2-methylphenyl)-N-(1-methoxyhexan-3-y...)
Show SMILES CCCC(CCOC)Nc1nc(C)nc2n(ncc12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C21H29N5O2/c1-6-7-16(10-11-27-4)25-20-18-13-22-26(21(18)24-15(3)23-20)19-9-8-17(28-5)12-14(19)2/h8-9,12-13,16H,6-7,10-11H2,1-5H3,(H,23,24,25)
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132n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302575
PNG
(1-(4-methoxy-2-methylphenyl)-N-((S)-1-methoxybutan...)
Show SMILES CC[C@@H](COC)Nc1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C20H27N5O2/c1-7-15(11-26-5)23-19-18-13(3)24-25(20(18)22-14(4)21-19)17-9-8-16(27-6)10-12(17)2/h8-10,15H,7,11H2,1-6H3,(H,21,22,23)/t15-/m0/s1
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135n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302600
PNG
(1-(6-(dimethylamino)-2,4-dimethylpyridin-3-yl)-N-(...)
Show SMILES CCCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1cnc(cc1C)N(C)C
Show InChI InChI=1S/C21H31N7O/c1-8-9-27(10-11-29-7)20-19-15(3)25-28(21(19)24-16(4)23-20)17-13-22-18(26(5)6)12-14(17)2/h12-13H,8-11H2,1-7H3
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183n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302585
PNG
(1-(4-methoxy-2-methylphenyl)-N,N-bis(2-methoxyethy...)
Show SMILES COCCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C21H29N5O3/c1-14-13-17(29-6)7-8-18(14)26-21-19(15(2)24-26)20(22-16(3)23-21)25(9-11-27-4)10-12-28-5/h7-8,13H,9-12H2,1-6H3
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193n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302576
PNG
(1-(4-methoxy-2-methylphenyl)-N-((R)-1-methoxybutan...)
Show SMILES CC[C@H](COC)Nc1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C20H27N5O2/c1-7-15(11-26-5)23-19-18-13(3)24-25(20(18)22-14(4)21-19)17-9-8-16(27-6)10-12(17)2/h8-10,15H,7,11H2,1-6H3,(H,21,22,23)/t15-/m1/s1
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210n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302597
PNG
(4-(4-((2-methoxyethyl)(propyl)amino)-3,6-dimethyl-...)
Show SMILES CCCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1ccc(cc1C)C(N)=O
Show InChI InChI=1S/C21H28N6O2/c1-6-9-26(10-11-29-5)20-18-14(3)25-27(21(18)24-15(4)23-20)17-8-7-16(19(22)28)12-13(17)2/h7-8,12H,6,9-11H2,1-5H3,(H2,22,28)
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275n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302591
PNG
(1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-N-(2-((p...)
Show SMILES CCCNCc1nccn1Nc1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C22H28N8O/c1-6-9-23-13-19-24-10-11-29(19)28-21-20-15(3)27-30(22(20)26-16(4)25-21)18-8-7-17(31-5)12-14(18)2/h7-8,10-12,23H,6,9,13H2,1-5H3,(H,25,26,28)
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400n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302578
PNG
((2S)-2-(1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-...)
Show SMILES CCC[C@@H](CO)Nc1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C20H27N5O2/c1-6-7-15(11-26)23-19-18-13(3)24-25(20(18)22-14(4)21-19)17-9-8-16(27-5)10-12(17)2/h8-10,15,26H,6-7,11H2,1-5H3,(H,21,22,23)/t15-/m0/s1
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574n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302601
PNG
(5-(4-((2-methoxyethyl)(propyl)amino)-3,6-dimethyl-...)
Show SMILES CCCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1ccc(nc1C)C(N)=O
Show InChI InChI=1S/C20H27N7O2/c1-6-9-26(10-11-29-5)19-17-13(3)25-27(20(17)24-14(4)23-19)16-8-7-15(18(21)28)22-12(16)2/h7-8H,6,9-11H2,1-5H3,(H2,21,28)
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577n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302579
PNG
((2S)-2-(1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-...)
Show SMILES CC[C@@H](CO)Nc1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C19H25N5O2/c1-6-14(10-25)22-18-17-12(3)23-24(19(17)21-13(4)20-18)16-8-7-15(26-5)9-11(16)2/h7-9,14,25H,6,10H2,1-5H3,(H,20,21,22)/t14-/m0/s1
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620n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302596
PNG
(4-(4-((2-methoxyethyl)(propyl)amino)-3,6-dimethyl-...)
Show SMILES CCCN(CCOC)c1nc(C)nc2n(nc(C)c12)-c1ccc(cc1C#N)C#N
Show InChI InChI=1S/C21H23N7O/c1-5-8-27(9-10-29-4)20-19-14(2)26-28(21(19)25-15(3)24-20)18-7-6-16(12-22)11-17(18)13-23/h6-7,11H,5,8-10H2,1-4H3
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632n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302588
PNG
(CHEMBL568607 | N-(1-(4-methoxy-2-methylphenyl)-3,6...)
Show SMILES CCCNCc1nnc(Nc2nc(C)nc3n(nc(C)c23)-c2ccc(OC)cc2C)o1
Show InChI InChI=1S/C21H26N8O2/c1-6-9-22-11-17-26-27-21(31-17)25-19-18-13(3)28-29(20(18)24-14(4)23-19)16-8-7-15(30-5)10-12(16)2/h7-8,10,22H,6,9,11H2,1-5H3,(H,23,24,25,27)
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996n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302580
PNG
((2R)-2-(1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-...)
Show SMILES CC[C@H](CO)Nc1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C19H25N5O2/c1-6-14(10-25)22-18-17-12(3)23-24(19(17)21-13(4)20-18)16-8-7-15(26-5)9-11(16)2/h7-9,14,25H,6,10H2,1-5H3,(H,20,21,22)/t14-/m1/s1
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1.13E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302587
PNG
(2-((1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-1H-p...)
Show SMILES CCCN(CC(=O)N(C)C)c1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C22H30N6O2/c1-8-11-27(13-19(29)26(5)6)21-20-15(3)25-28(22(20)24-16(4)23-21)18-10-9-17(30-7)12-14(18)2/h9-10,12H,8,11,13H2,1-7H3
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1.41E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50302592
PNG
(1-(4-methoxy-2-methylphenyl)-3,6-dimethyl-N-(5-((p...)
Show SMILES CCCNCc1cncn1Nc1nc(C)nc2n(nc(C)c12)-c1ccc(OC)cc1C
Show InChI InChI=1S/C22H28N8O/c1-6-9-23-11-17-12-24-13-29(17)28-21-20-15(3)27-30(22(20)26-16(4)25-21)19-8-7-18(31-5)10-14(19)2/h7-8,10,12-13,23H,6,9,11H2,1-5H3,(H,25,26,28)
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2.50E+3n/an/an/an/an/an/an/an/a



Pfizer Global Research and Development

Curated by ChEMBL


Assay Description
Antagonist activity at human recombinant CRF1 receptor expressed in CHO cells assessed as inhibition of CRF-induced cAMP production


Bioorg Med Chem Lett 19: 6144-7 (2009)


Article DOI: 10.1016/j.bmcl.2009.09.016
BindingDB Entry DOI: 10.7270/Q2FT8M46
More data for this
Ligand-Target Pair