Compile Data Set for Download or QSAR
Report error Found 89 Enz. Inhib. hit(s) with all data for entry = 50049028
TargetNuclear receptor subfamily 1 group I member 2(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864 | US12065447, Compound GSK2982772)
Affinity DataEC50:  1.30E+4nMAssay Description:Activation of human PXRMore data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233227(CHEMBL4067372)
Affinity DataIC50: 0.0500nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159697(CHEMBL3785745)
Affinity DataIC50: 0.0630nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233256(CHEMBL4093220)
Affinity DataIC50: 0.0790nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159696(CHEMBL3786997)
Affinity DataIC50: 0.200nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233248(CHEMBL4096224)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233244(CHEMBL4068954)
Affinity DataIC50: 0.320nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864 | US12065447, Compound GSK2982772)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of RIP1 in human primary neutrophils assessed as reduction in TNFalpha/QCD-OPh/SMAC mimetic RMT 5265-induced necroptosis at 21 hrs post-st...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233255(CHEMBL4069318)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233228(CHEMBL4060644)
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233226(CHEMBL4089558)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233230(CHEMBL4099004)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864 | US12065447, Compound GSK2982772)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of RIP1 in human primary neutrophils assessed as reduction in TNFalpha/QCD-OPh/SMAC mimetic RMT 5265-MIP-1beta production at 21 hrs post-s...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233249(CHEMBL4081685)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233240(CHEMBL4065561)
Affinity DataIC50: 0.630nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233229(CHEMBL4088857)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159508(CHEMBL3786078)
Affinity DataIC50: 0.790nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864 | US12065447, Compound GSK2982772)
Affinity DataIC50: 1nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233227(CHEMBL4067372)
Affinity DataIC50: 1nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233252(CHEMBL4080978)
Affinity DataIC50: 1nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233250(CHEMBL4099698)
Affinity DataIC50: 1nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233240(CHEMBL4065561)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864 | US12065447, Compound GSK2982772)
Affinity DataIC50: 1.60nMAssay Description:Inhibition of RIP1 in human primary neutrophils assessed as reduction in TNFalpha/QCD-OPh/SMAC mimetic RMT 5265-induced necroptosis by measuring cell...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864 | US12065447, Compound GSK2982772)
Affinity DataIC50: 2nMAssay Description:Inhibition of RIP1 in human whole blood assessed as reduction in TNFalpha/QCD-OPh/zVAD FMK/SMAC mimetic RMT 5265-MIP-1beta production after 6 hrs by ...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233241(CHEMBL4071080)
Affinity DataIC50: 2nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159697(CHEMBL3785745)
Affinity DataIC50: 2nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233256(CHEMBL4093220)
Affinity DataIC50: 2.5nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233226(CHEMBL4089558)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233242(CHEMBL4069959)
Affinity DataIC50: 5nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233230(CHEMBL4099004)
Affinity DataIC50: 5nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233250(CHEMBL4099698)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159696(CHEMBL3786997)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864 | US12065447, Compound GSK2982772)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233255(CHEMBL4069318)
Affinity DataIC50: 6.30nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233229(CHEMBL4088857)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233244(CHEMBL4068954)
Affinity DataIC50: 7.90nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233248(CHEMBL4096224)
Affinity DataIC50: 10nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233228(CHEMBL4060644)
Affinity DataIC50: 10nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233249(CHEMBL4081685)
Affinity DataIC50: 13nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233225(CHEMBL4071864 | US12065447, Compound GSK2982772)
Affinity DataIC50: 16nMAssay Description:Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)-amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159512(CHEMBL3786293)
Affinity DataIC50: 16nMAssay Description:Inhibition of human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated for 1 hr followed by ATP addition measured a...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233242(CHEMBL4069959)
Affinity DataIC50: 20nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233252(CHEMBL4080978)
Affinity DataIC50: 25nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159512(CHEMBL3786293)
Affinity DataIC50: 32nMAssay Description:Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)-amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233241(CHEMBL4071080)
Affinity DataIC50: 40nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50159508(CHEMBL3786078)
Affinity DataIC50: 40nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233231(CHEMBL4096551)
Affinity DataIC50: 63nMAssay Description:Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)-amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233247(CHEMBL4062496)
Affinity DataIC50: 100nMAssay Description:Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)-amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233247(CHEMBL4062496)
Affinity DataIC50: 126nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in TNFalpha/QVD-Oph-induced necrosis after 24 hrs by Cell Titer-Glo luminescent cell via...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
TargetReceptor-interacting serine/threonine-protein kinase 1(Human)
Queen Mary University of London

Curated by ChEMBL
LigandPNGBDBM50233236(CHEMBL4098676)
Affinity DataIC50: 200nMAssay Description:Displacement of (14-(2-{[3-({2-{[4-(cyanomethyl)phenyl]amino}-6-[(5-cyclopropyl-1H-pyrazol-3-yl)-amino]-4-pyrimidinyl}amino)propyl]amino}-2-oxoethyl)...More data for this Ligand-Target Pair
In DepthDetails Article
PubMed
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