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Found 4 Enz. Inhib. hit(s) with Target = '5'-nucleotidase' and Ligand = 'BDBM50561236'
Target5'-nucleotidase(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561236(CHEMBL4786598 | US11325938, Ex 86)
Affinity DataIC50:  0.570nMAssay Description:Inhibition of human C-terminal His6-tagged CD73 expressed in CHO cells preincubated for 15 mins followed by AMP addition and measured after 10 mins b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561236(CHEMBL4786598 | US11325938, Ex 86)
Affinity DataIC50: <100nMAssay Description:Assay Reaction ConditionsAssay Volume: 70 μlReaction Volume: 50 μlCD73: 0.3208 nMAMP: 15 μMAssay Buffer: 25 mM Tris-HCL, pH 7.4, 0.01%...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
Target5'-nucleotidase(Mus musculus)
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561236(CHEMBL4786598 | US11325938, Ex 86)
Affinity DataEC50:  46nMAssay Description:Inhibition of CD73 in mouse EMT6 cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and meas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5'-nucleotidase(Homo sapiens (Human))
Oric Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50561236(CHEMBL4786598 | US11325938, Ex 86)
Affinity DataEC50:  3.70nMAssay Description:Inhibition of CD73 in human NCI-H1568 cells assessed as reduction in AMP-induced ADO expression preincubated for 15 mins followed by AMP addition and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed