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Found 3 Enz. Inhib. hit(s) with Target = 'Hepatocyte growth factor receptor' and Ligand = 'BDBM50302903'
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50302903(7-methoxy-N-((6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Affinity DataKi:  2.70nM ΔG°:  -49.2kJ/molepH: 8.0 T: 2°CAssay Description:A PCR product covering residues 1058-1365 of c-Met (c-Met kinase domain) is generated from Human Liver QuickClone cDNA (Invitrogen) using forward pri...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50302903(7-methoxy-N-((6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Affinity DataIC50:  5nMAssay Description:Inhibition of c-Met by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50302903(7-methoxy-N-((6-(3,4,5-trifluorophenyl)-[1,2,4]tri...)
Affinity DataIC50:  7nMAssay Description:Inhibition of HGF-mediated human c-Met autophosphorylation expressed in human PC3 cells after 1 hr by electrochemiluminescent immunoassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed