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Found 20 Enz. Inhib. hit(s) with Target = 'Melanocyte-stimulating hormone receptor' and Ligand = 'BDBM50184359'
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  0.100nMAssay Description:Displacement of [125I]NDP-alpha-MSH from human MC1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  0.200nMAssay Description:Displacement of [125I]NDP-alphaMSH from human MC1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  0.200nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  0.200nMAssay Description:Inhibitory activity against hMC1R transfected in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  0.25nMAssay Description:Inhibitory concentration against human Melanocortin 1 receptor (hMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  0.5nMAssay Description:The concentration that inhibits 50% specific binding was determined against the Melanocortin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  1nMAssay Description:Binding affinity towards human melanocortin receptor (hMC1R) using NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataIC50:  2.30nMAssay Description:Displacement of [125I]-NDP-alpha-MSH from human MC1R expressed in HEK293 cells after 40 mins by Wallac 1470 gamma countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataEC50:  1nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as increase in intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataEC50:  0.300nMAssay Description:Agonist activity at human MC1R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Mus musculus)
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataEC50:  0.0200nMAssay Description:Activity in mouse melanocortin-1 receptor stably expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataEC50:  1nMAssay Description:Activity at human MC1R expressed in HEK293 cells assessed by measuring intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataEC50:  0.300nMAssay Description:Activity at hMC1R transfected in HEK293 cells assessed as intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Mus musculus)
University Of Florida

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataEC50:  0.0200nMAssay Description:Agonist activity to the mouse Melanocortin-1 receptor (mMC1R)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataEC50:  0.150nMAssay Description:Effective concentration against Melanocortin 1 receptor transfected into L-cells was determined by concentration of peptide for 50% maximal cAMP gene...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataEC50:  0.600nMAssay Description:Binding affinity towards human melanocortin receptor (hMC4R) using NDP-MSH as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataEC50:  0.300nMAssay Description:Activity against hMC1R transfected in HEK293 cells by intracellular cAMP accumulationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataEC50:  0.100nMAssay Description:Decrease in frog skin reflectivity (melanotropic activity).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataEC50:  0.100nMAssay Description:Effective concentration for the effect of Melanocortin 1 receptor in the frog skin.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMelanocyte-stimulating hormone receptor(Homo sapiens (Human))
University Of Arizona

Curated by ChEMBL
LigandPNGBDBM50184359((3S,6S,9R,12S,15S,23S)-15-((S)-2-acetylamino-hexan...)
Affinity DataEC50:  0.190nMAssay Description:Effective concentration for intracellular cAMP accumulation in L-cells expressing Melanocortin 1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed