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Found 40 Enz. Inhib. hit(s) with Target = 'Mu-type opioid receptor' and Ligand = 'BDBM50001465'
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membrane incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cell membrane incubated for 90 mins by liquid scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity was determined towards Opioid receptor mu 1 in rat brain synaptosomes using [3H]-DAMGO as radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  2.53nMAssay Description:Evaluated for its ability to displace [3H]DAGO binding to Opioid receptor mu 1 from rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  3.40nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(MOUSE)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  6.58nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  6.60nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  7.40nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(MOUSE)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  9.16nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  9.40nMAssay Description:Tested for binding affinity towards Opioid receptor mu 1 in rat and guinea pig brain membrane binding assaysMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  9.40nMAssay Description:Binding affinity of Opioid receptor mu 1 mu 1 by the displacement of mu-selective [3H]DAGO from brain membrane preparations.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  9.40nMAssay Description:Binding affinity against Opioid receptor mu 1 by displacement of radioligand [3H]-DAGO in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  9.40nMAssay Description:. Binding affinity for Opioid receptor mu 1 determined by displacing [3H]-DAMGO from rat brain membrane binding sitesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  9.40nMAssay Description:Binding affinity for mu opioid receptors by displacement of [3H]-DAMGO from rat brain membrane binding siteMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  9.40nMAssay Description:Tested for binding affinity against mu opioid receptor fby displacing [3H]- DAMGO radioligand from rat brain membrane preparationsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  9.40nMAssay Description:Inhibition of [3H]- ]DAMGO binding to opioid receptor mu from rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  9.40nMAssay Description:The compound was tested for the ability to displace Opioid receptor mu 1 specific radioligand [3H]DAGOMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  9.43nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  21.7nMMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  24nMAssay Description:Binding affinity of the compound towards Opioid receptor mu 1 was determined using ([d-Ala2,MePhe4, Gly5-ol]-enkephalin (DAMGO) as the radioligand.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  28nMAssay Description:Inhibition of binding of [3H]naloxone to Opioid receptor mu 1 in the rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  380nMAssay Description:Binding affinity against Opioid receptor mu 1 of guinea pig brain membranes using 0.5 nM of [3H]naloxone as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Danio rerio)
Instituto De Qu£Mica Avanzada De Catalu£A (Iqac-Csic)

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  1.32E+3nMAssay Description:Displacement of [3H]DPN from zebrafish mu opioid receptor expressed in HEK293 cell membranes after 1 hr by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataKi:  4.80E+3nMAssay Description:Binding affinity towards non-selective opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50:  9.40nMAssay Description:Ability to induce 50% of maximal effect in mouse vas deferens expressing Opioid receptor delta 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(MOUSE)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50:  20nMAssay Description:Agonist activity at FLAG-tagged mouse mu opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin stimulated cAMP producti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(MOUSE)
Memorial Sloan-Kettering Cancer Center

Curated by PDSP Ki Database
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50:  20nMAssay Description:Agonist activity at FLAG-tagged mouse mu opioid receptor expressed in human HEK293 cells assessed as inhibition of forskolin stimulated cAMP producti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50:  50nMAssay Description:Inhibition of binding of [3H]naloxone to Opioid receptor mu 1 in the rat brain homogenateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50:  103nMAssay Description:In vitro inhibitory activity was determined against Opioid receptor mu 1 in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50:  246nMAssay Description:Agonist activity at mu opioid receptor in guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50:  246nMAssay Description:Antagonist activity at MOR in guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50:  246nMAssay Description:Inhibitory potency against Opioid receptor mu 1 in the guinea pig ileum assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(GUINEA PIG)
University Of Minnesota

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50:  246nMAssay Description:Inhibition of electrically evoked contractions in Guinea pig ileumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataIC50:  9.50E+3nMAssay Description:Binding affinity towards non-selective opiate receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataEC50:  794nMAssay Description:Agonist activity at MOP (unknown origin) expressed in SH-SY5Y cell membranes co-expressing beta-arrestin2-RGFP protein assessed as induction of beta-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataEC50:  1.30nMAssay Description:Agonist activity at mu opioid receptor (unknown origin) expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataEC50:  1.27E+3nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitment measured afte...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataEC50:  1.29E+3nMAssay Description:Agonist activity at human mu opioid receptor expressed in CHO cells co-expressing beta-arrestin2 assessed as beta-arrestin2 recruitment measured afte...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetMu-type opioid receptor(Homo sapiens (Human))
The Ohio State University

Curated by ChEMBL
LigandPNGBDBM50001465((S)-2-[(S)-2-(2-{2-[(S)-2-Amino-3-(4-hydroxy-pheny...)
Affinity DataEC50:  178nMAssay Description:Agonist activity at MOP (unknown origin) expressed in SH-SY5Y cell membranes co-expressing Gbeta1-RGFP protein assessed as induction of G protein act...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed